Literature DB >> 18850185

Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid.

Elena Darra1, Kazuo Shoji, Sofia Mariotto, Hisanori Suzuki.   

Abstract

The beneficial effect of naturally occurring flavonoids in health is believed to be due to their strong antioxidant activity. However, recent laboratory evidence indicates the involvement of a more specific action. Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). Protective action of EGCG in ischemia/reperfusion injury in the heart and the molecular mechanism of action, which has nothing to do with its anti-oxidant capacity are described.

Entities:  

Year:  2007        PMID： 18850185      PMCID： PMC2474938          DOI： 10.1007/s12263-007-0060-3

Source DB:  PubMed          Journal:  Genes Nutr        ISSN： 1555-8932            Impact factor:   5.523


  40 in total

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Review 2.  A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases.

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Review 6.  Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications.

Authors:  Nurulain T Zaveri
Journal:  Life Sci       Date:  2006-01-30       Impact factor: 5.037

7.  Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.

Authors:  Joanne Rasschaert; Laurence Ladrière; Maryse Urbain; Zeynep Dogusan; Bitty Katabua; Shintaro Sato; Shizuo Akira; Conny Gysemans; Chantal Mathieu; Decio L Eizirik
Journal:  J Biol Chem       Date:  2005-07-15       Impact factor: 5.157

Review 8.  Beneficial effects of green tea--a review.

Authors:  Carmen Cabrera; Reyes Artacho; Rafael Giménez
Journal:  J Am Coll Nutr       Date:  2006-04       Impact factor: 3.169

9.  Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils.

Authors:  Hyung Lee; Jae Hoon Bae; Seong-Ryong Lee
Journal:  J Neurosci Res       Date:  2004-09-15       Impact factor: 4.164

Review 10.  Antimutagenic and anticarcinogenic activity of tea polyphenols.

Authors:  Y Kuroda; Y Hara
Journal:  Mutat Res       Date:  1999-01       Impact factor: 2.433
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  6 in total

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4.  STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy.

Authors:  J McCormick; N Suleman; T M Scarabelli; R A Knight; D S Latchman; A Stephanou
Journal:  J Cell Mol Med       Date:  2012-02       Impact factor: 5.310

5.  Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity.

Authors:  Vikrant Borse; Raheem F H Al Aameri; Kelly Sheehan; Sandeep Sheth; Tejbeer Kaur; Debashree Mukherjea; Srinivasan Tupal; Michelle Lowy; Sumana Ghosh; Asmita Dhukhwa; Puspanjali Bhatta; Leonard P Rybak; Vickram Ramkumar
Journal:  Cell Death Dis       Date:  2017-07-13       Impact factor: 8.469

6.  E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis.

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  6 in total

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