Literature DB >> 18850053

SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145.

Xijun Ou1, Bo Zhang, Lin Zhang, Kai Dong, Chun Liu, Guoping Zhao, Xiaoming Ding.   

Abstract

The filamentous bacteria Streptomyces exhibit a complex life cycle involving morphological differentiation and secondary metabolism. A putative membrane protein gene sarA (sco4069), sporulation and antibiotic production related gene A, was partially characterized in Streptomyces coelicolor M145. The gene product had no characterized functional domains and was highly conserved in Streptomyces. Compared with the wild-type M145, the sarA mutant accelerated sporulation and dramatically decreased the production of actinorhodin and undecylprodigiosin. Reverse transcription-polymerase chain reaction analysis showed that SarA influenced antibiotic production by controlling the abundance of actII-orf4 and redZ messenger RNA.

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Year:  2008        PMID： 18850053

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  7 in total

1.  RifZ (AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei.

Authors:  Chen Li; Xinqiang Liu; Chao Lei; Han Yan; Zhihui Shao; Ying Wang; Guoping Zhao; Jin Wang; Xiaoming Ding
Journal:  Appl Environ Microbiol       Date:  2017-03-31       Impact factor: 4.792

2.  Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis.

Authors:  Zhong Xu; Yemin Wang; Keith F Chater; Hong-Yu Ou; H Howard Xu; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2017-03-02       Impact factor: 4.792

3.  Effects of carbon ion beam-induced mutagenesis for the screening of RED production-deficient mutants of Streptomyces coelicolor JCM4020.

Authors:  Masaomi Yanagisawa; Shumpei Asamizu; Katsuya Satoh; Yutaka Oono; Hiroyasu Onaka
Journal:  PLoS One       Date:  2022-07-14       Impact factor: 3.752

4.  Quantitative Proteome and Phosphoproteome Analyses of Streptomyces coelicolor Reveal Proteins and Phosphoproteins Modulating Differentiation and Secondary Metabolism.

Authors:  Beatriz Rioseras; Pavel V Shliaha; Vladimir Gorshkov; Paula Yagüe; María T López-García; Nathaly Gonzalez-Quiñonez; Sergey Kovalchuk; Adelina Rogowska-Wrzesinska; Ole N Jensen; Angel Manteca
Journal:  Mol Cell Proteomics       Date:  2018-05-21       Impact factor: 5.911

5.  Transcriptomic analysis of Streptomyces coelicolor differentiation in solid sporulating cultures: first compartmentalized and second multinucleated mycelia have different and distinctive transcriptomes.

Authors:  Paula Yagüe; Antonio Rodríguez-García; María T López-García; Juan F Martín; Beatriz Rioseras; Jesús Sánchez; Angel Manteca
Journal:  PLoS One       Date:  2013-03-28       Impact factor: 3.240

6.  Transcriptomic analysis of liquid non-sporulating Streptomyces coelicolor cultures demonstrates the existence of a complex differentiation comparable to that occurring in solid sporulating cultures.

Authors:  Paula Yagüe; Antonio Rodríguez-García; María Teresa López-García; Beatriz Rioseras; Juan Francisco Martín; Jesús Sánchez; Angel Manteca
Journal:  PLoS One       Date:  2014-01-21       Impact factor: 3.240

7.  Genome-Wide Mutagenesis Links Multiple Metabolic Pathways with Actinorhodin Production in Streptomyces coelicolor.

Authors:  Zhong Xu; Yuanyuan Li; Yemin Wang; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2019-03-22       Impact factor: 4.792
  7 in total

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