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Literature DB >> 18849991

Male-pattern baldness susceptibility locus at 20p11.

J Brent Richards¹, Xin Yuan, Frank Geller, Dawn Waterworth, Veronique Bataille, Daniel Glass, Kijoung Song, Gerard Waeber, Peter Vollenweider, Katja K H Aben, Lambertus A Kiemeney, Bragi Walters, Nicole Soranzo, Unnur Thorsteinsdottir, Augustine Kong, Thorunn Rafnar, Panos Deloukas, Patrick Sulem, Hreinn Stefansson, Kari Stefansson, Tim D Spector, Vincent Mooser.

Abstract

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

Entities: Disease Gene Mutation Species

Mesh：

Year: 2008 PMID： 18849991 PMCID： PMC2672151 DOI： 10.1038/ng.255

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

13 in total

1. Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome.

Authors: Joan C Lo; Seth L Feigenbaum; Jingrong Yang; Alice R Pressman; Joe V Selby; Alan S Go
Journal: J Clin Endocrinol Metab Date: 2006-01-24 Impact factor: 5.958

2. EDA2R is associated with androgenetic alopecia.

Authors: Dionigio Antonio Prodi; Nicola Pirastu; Giuseppe Maninchedda; Alessandro Sassu; Andrea Picciau; Maria Antonietta Palmas; Alessandra Mossa; Ivana Persico; Mauro Adamo; Andrea Angius; Mario Pirastu
Journal: J Invest Dermatol Date: 2008-04-03 Impact factor: 8.551

3. Confirmation of the association between male pattern baldness and the androgen receptor gene.

Authors: Etgar Levy-Nissenbaum; Michal Bar-Natan; Moshe Frydman; Elon Pras
Journal: Eur J Dermatol Date: 2005 Sep-Oct Impact factor: 3.328

4. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.

Authors: Axel M Hillmer; Sandra Hanneken; Sibylle Ritzmann; Tim Becker; Jan Freudenberg; Felix F Brockschmidt; Antonia Flaquer; Yun Freudenberg-Hua; Rami Abou Jamra; Christine Metzen; Uwe Heyn; Nadine Schweiger; Regina C Betz; Bettina Blaumeiser; Jochen Hampe; Stefan Schreiber; Thomas G Schulze; Hans Christian Hennies; Johannes Schumacher; Peter Propping; Thomas Ruzicka; Sven Cichon; Thomas F Wienker; Roland Kruse; Markus M Nothen
Journal: Am J Hum Genet Date: 2005-05-18 Impact factor: 11.025

5. The E211 G>A androgen receptor polymorphism is associated with a decreased risk of metastatic prostate cancer and androgenetic alopecia.

Authors: Vanessa M Hayes; Gianluca Severi; Sarah A Eggleton; Emma J D Padilla; Melissa C Southey; Robert L Sutherland; John L Hopper; Graham G Giles
Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-04 Impact factor: 4.254

6. Reliability and validity of self-reported male balding patterns for use in epidemiologic studies.

Authors: Alyson J Littman; Emily White
Journal: Ann Epidemiol Date: 2005-06-09 Impact factor: 3.797

7. Psychological effects of androgenetic alopecia on women: comparisons with balding men and with female control subjects.

Authors: T F Cash; V H Price; R C Savin
Journal: J Am Acad Dermatol Date: 1993-10 Impact factor: 11.527

8. The feasibility of targeted selective gene therapy of the hair follicle.

Authors: L Li; R M Hoffman
Journal: Nat Med Date: 1995-07 Impact factor: 53.440

Review 9. Long-range control of gene expression: emerging mechanisms and disruption in disease.

Authors: Dirk A Kleinjan; Veronica van Heyningen
Journal: Am J Hum Genet Date: 2004-11-17 Impact factor: 11.025

10. LDL-cholesterol concentrations: a genome-wide association study.

Authors: Manjinder S Sandhu; Dawn M Waterworth; Sally L Debenham; Eleanor Wheeler; Konstantinos Papadakis; Jing Hua Zhao; Kijoung Song; Xin Yuan; Toby Johnson; Sofie Ashford; Michael Inouye; Robert Luben; Matthew Sims; David Hadley; Wendy McArdle; Philip Barter; Y Antero Kesäniemi; Robert W Mahley; Ruth McPherson; Scott M Grundy; Sheila A Bingham; Kay-Tee Khaw; Ruth J F Loos; Gérard Waeber; Inês Barroso; David P Strachan; Panagiotis Deloukas; Peter Vollenweider; Nicholas J Wareham; Vincent Mooser
Journal: Lancet Date: 2008-02-09 Impact factor: 79.321

32 in total

1. Prediction of male-pattern baldness from genotypes.

Authors: Fan Liu; Merel A Hamer; Stefanie Heilmann; Christine Herold; Susanne Moebus; Albert Hofman; André G Uitterlinden; Markus M Nöthen; Cornelia M van Duijn; Tamar Ec Nijsten; Manfred Kayser
Journal: Eur J Hum Genet Date: 2015-10-28 Impact factor: 4.246

2. Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture.

Authors: J Brent Richards; Fotini K Kavvoura; Fernando Rivadeneira; Unnur Styrkársdóttir; Karol Estrada; Bjarni V Halldórsson; Yi-Hsiang Hsu; M Carola Zillikens; Scott G Wilson; Benjamin H Mullin; Najaf Amin; Yurii S Aulchenko; L Adrienne Cupples; Panagiotis Deloukas; Serkalem Demissie; Albert Hofman; Augustine Kong; David Karasik; Joyce B van Meurs; Ben A Oostra; Huibert A P Pols; Gunnar Sigurdsson; Unnur Thorsteinsdottir; Nicole Soranzo; Frances M K Williams; Yanhua Zhou; Stuart H Ralston; Gudmar Thorleifsson; Cornelia M van Duijn; Douglas P Kiel; Kari Stefansson; André G Uitterlinden; John P A Ioannidis; Tim D Spector
Journal: Ann Intern Med Date: 2009-10-20 Impact factor: 25.391

Review 3. [Genetic hair diseases. An update].

Authors: J Frank; P Poblete-Gutiérrez; K Giehl
Journal: Hautarzt Date: 2013-11 Impact factor: 0.751

4. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.

Authors: Luis A Garza; Yaping Liu; Zaixin Yang; Brinda Alagesan; John A Lawson; Scott M Norberg; Dorothy E Loy; Tailun Zhao; Hanz B Blatt; David C Stanton; Lee Carrasco; Gurpreet Ahluwalia; Susan M Fischer; Garret A FitzGerald; George Cotsarelis
Journal: Sci Transl Med Date: 2012-03-21 Impact factor: 17.956

Review 5. The role of androgen and androgen receptor in skin-related disorders.

Authors: Jiann-Jyh Lai; Philip Chang; Kuo-Pao Lai; Lumin Chen; Chawnshang Chang
Journal: Arch Dermatol Res Date: 2012-07-25 Impact factor: 3.017

6. eXclusion: toward integrating the X chromosome in genome-wide association analyses.

Authors: Anastasia L Wise; Lin Gyi; Teri A Manolio
Journal: Am J Hum Genet Date: 2013-05-02 Impact factor: 11.025

Review 7. Androgenetic alopecia: a review.

Authors: Francesca Lolli; Francesco Pallotti; Alfredo Rossi; Maria C Fortuna; Gemma Caro; Andrea Lenzi; Andrea Sansone; Francesco Lombardo
Journal: Endocrine Date: 2017-03-28 Impact factor: 3.633