| Literature DB >> 18849110 |
Philipp Bastian1, Agnieszka Balcarek, Christina Altanis, Carina Strell, Bernd Niggemann, Kurt S Zaenker, Frank Entschladen.
Abstract
Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibitory effect is possibly mediated by a cAMP-dependent activation of the small GTPase Rap1 via Epac. Furthermore, a key signalling event of the promigratory effect of norepinephrine in the above mentioned carcinoma cells is the activation of phospholipase C enzymes. In ES-2 cells, this part of the signalling cascade is constitutively active.Entities:
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Year: 2008 PMID： 18849110 DOI： 10.1016/j.canlet.2008.09.008
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679