Literature DB >> 18849029

Studies of the human aortic intima by a direct quantitative assay of mutant alleles in the mitochondrial genome.

M Sazonova1, E Budnikov, Z Khasanova, I Sobenin, A Postnov, A Orekhov, A Orehov.   

Abstract

A mutant allele quantitative assay was developed to study somatic mitochondrial mutations associated with human diseases. This assay may be used in the clinical diagnostics for diseases associated with somatic mutations. To detect somatic mutations associated with atherosclerotic lesions of the aortal intima, we analyzed 40 mitochondrial mutations previously identified in several pathological conditions. 10 mutations associated with lipofibrosis plaques were found in mitochondrial genes that encode rRNA 12S, tRNA-Leu (UUR recognition codon), tRNA-Leu (CUN recognition codon), subunits of 1, 2, 5, and 6 NADH-dehydrogenase, and cytochrome B.

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Year:  2008        PMID： 18849029     DOI： 10.1016/j.atherosclerosis.2008.09.001

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  22 in total

Review 1.  Role of somatic mutations in vascular disease formation.

Authors:  Sarah M Weakley; Jun Jiang; Panagiotis Kougias; Peter H Lin; Qizhi Yao; F Charles Brunicardi; Richard A Gibbs; Changyi Chen
Journal:  Expert Rev Mol Diagn       Date:  2010-03       Impact factor: 5.225

2.  DNA Methylation-a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy.

Authors:  Manish Mishra; Renu A Kowluru
Journal:  Mol Neurobiol       Date:  2018-04-21       Impact factor: 5.590

Review 3.  Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.

Authors:  Emanuele Marzetti; Anna Csiszar; Debapriya Dutta; Gauthami Balagopal; Riccardo Calvani; Christiaan Leeuwenburgh
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-06-07       Impact factor: 4.733

Review 4.  Mitochondria and cardiovascular aging.

Authors:  Dao-Fu Dai; Peter S Rabinovitch; Zoltan Ungvari
Journal:  Circ Res       Date:  2012-04-13       Impact factor: 17.367

5.  Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes.

Authors:  Dimitry A Chistiakov; Igor A Sobenin; Yuri V Bobryshev; Alexander N Orekhov
Journal:  World J Cardiol       Date:  2012-05-26

6.  Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension.

Authors:  Igor A Sobenin; Dimitry A Chistiakov; Margarita A Sazonova; Maria M Ivanova; Yuri V Bobryshev; Alexander N Orekhov; Anton Y Postnov
Journal:  World J Cardiol       Date:  2013-05-26

Review 7.  Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target.

Authors:  Dan Li; Shengjie Yang; Yanwei Xing; Limin Pan; Ran Zhao; Yixi Zhao; Longtao Liu; Min Wu
Journal:  Front Cell Dev Biol       Date:  2021-07-07

8.  Mitochondrial mutations are associated with atherosclerotic lesions in the human aorta.

Authors:  Igor A Sobenin; Margarita A Sazonova; Anton Y Postnov; Yuri V Bobryshev; Alexander N Orekhov
Journal:  Clin Dev Immunol       Date:  2012-09-11

9.  Mutation C3256T of mitochondrial genome in white blood cells: novel genetic marker of atherosclerosis and coronary heart disease.

Authors:  Igor A Sobenin; Margarita A Sazonova; Maria M Ivanova; Andrey V Zhelankin; Veronika A Myasoedova; Anton Y Postnov; Serik D Nurbaev; Yuri V Bobryshev; Alexander N Orekhov
Journal:  PLoS One       Date:  2012-10-02       Impact factor: 3.240

10.  Mutations of mitochondrial genome in carotid atherosclerosis.

Authors:  Margarita A Sazonova; Andrey V Zhelankin; Valeria A Barinova; Vasily V Sinyov; Zukhra B Khasanova; Anton Y Postnov; Alexander N Orekhov; Yuri V Bobryshev; Igor A Sobenin
Journal:  Front Genet       Date:  2015-03-19       Impact factor: 4.599
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