Literature DB >> 18849025

Tachycardia-induced early afterdepolarizations: insights into potential ionic mechanisms from computer simulations.

Ray B Huffaker1, Richard Samade, James N Weiss, Boris Kogan.   

Abstract

Although early afterdepolarizations (EADs) are classically thought to occur at slow heart rates, mounting evidence suggests that EADs may also occur at rapid heart rates produced by tachyarrhythmias, due to Ca overload of the sarcoplasmic reticulum (SR) leading to spontaneous SR Ca release. We hypothesized that the mechanism of tachycardia-induced EADs depends on the spatial and temporal morphology of spontaneous SR Ca release, and tested this hypothesis in computer simulations using a ventricular action potential mathematical model. Using two previously suggested spontaneous release morphologies, we found two distinct tachycardia-induced EAD mechanisms: one mechanistically similar to bradycardia-induced EADs, the other to delayed afterdepolarizations (DADs).

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Year:  2008        PMID： 18849025      PMCID： PMC3089801          DOI： 10.1016/j.compbiomed.2008.08.010

Source DB:  PubMed          Journal:  Comput Biol Med        ISSN： 0010-4825            Impact factor:   4.589


  31 in total

1.  Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia.

Authors:  C E Clancy; Y Rudy
Journal:  Nature       Date:  1999-08-05       Impact factor: 49.962

Review 2.  Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts.

Authors:  P G Volders; M A Vos; B Szabo; K R Sipido; S H de Groot; A P Gorgels; H J Wellens; R Lazzara
Journal:  Cardiovasc Res       Date:  2000-06       Impact factor: 10.787

3.  Model of intracellular calcium cycling in ventricular myocytes.

Authors:  Y Shiferaw; M A Watanabe; A Garfinkel; J N Weiss; A Karma
Journal:  Biophys J       Date:  2003-12       Impact factor: 4.033

4.  Intracellular calcium handling heterogeneities in intact guinea pig hearts.

Authors:  Rodolphe P Katra; Etienne Pruvot; Kenneth R Laurita
Journal:  Am J Physiol Heart Circ Physiol       Date:  2003-10-09       Impact factor: 4.733

5.  Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome.

Authors:  Ray Huffaker; Scott T Lamp; James N Weiss; Boris Kogan
Journal:  Heart Rhythm       Date:  2004-10       Impact factor: 6.343

6.  Effects of early afterdepolarizations on reentry in cardiac tissue: a simulation study.

Authors:  Ray B Huffaker; James N Weiss; Boris Kogan
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-02-16       Impact factor: 4.733

7.  Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia.

Authors:  E Chudin; J Goldhaber; A Garfinkel; J Weiss; B Kogan
Journal:  Biophys J       Date:  1999-12       Impact factor: 4.033

8.  Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.

Authors:  W Shimizu; C Antzelevitch
Journal:  J Am Coll Cardiol       Date:  2000-03-01       Impact factor: 24.094

9.  Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.

Authors:  C E Clancy; Y Rudy
Journal:  Cardiovasc Res       Date:  2001-05       Impact factor: 10.787

10.  Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome.

Authors:  Bum-Rak Choi; Francis Burton; Guy Salama
Journal:  J Physiol       Date:  2002-09-01       Impact factor: 5.182
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  5 in total

1.  Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

Authors:  Zhenghang Zhao; Hairuo Wen; Nadezhda Fefelova; Charelle Allen; Akemichi Baba; Toshio Matsuda; Lai-Hua Xie
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-02-03       Impact factor: 4.733

2.  Models of HERG gating.

Authors:  Glenna C L Bett; Qinlian Zhou; Randall L Rasmusson
Journal:  Biophys J       Date:  2011-08-03       Impact factor: 4.033

3.  Bidirectional ventricular tachycardia: ping pong in the His-Purkinje system.

Authors:  Alex A Baher; Matthew Uy; Fagen Xie; Alan Garfinkel; Zhilin Qu; James N Weiss
Journal:  Heart Rhythm       Date:  2010-11-29       Impact factor: 6.343

Review 4.  Computational approaches to understand cardiac electrophysiology and arrhythmias.

Authors:  Byron N Roberts; Pei-Chi Yang; Steven B Behrens; Jonathan D Moreno; Colleen E Clancy
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-08-10       Impact factor: 4.733

5.  A Comparative Study of Early Afterdepolarization-Mediated Fibrillation in Two Mathematical Models for Human Ventricular Cells.

Authors:  Soling Zimik; Nele Vandersickel; Alok Ranjan Nayak; Alexander V Panfilov; Rahul Pandit
Journal:  PLoS One       Date:  2015-06-30       Impact factor: 3.240
  5 in total

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