OBJECTIVE: We examined the relation between Apolipoprotein E epsilon4 allele (ApoE epsilon4) genotype and functional connectivity measured by Electroencephalography (EEG) in patients with Alzheimer's disease (AD) and patients with subjective complaints (SC). METHODS: We included 43 patients with AD (age (SD)=74.2 (4.0), m/f=22/21; 30 of ApoE epsilon4 carriers) and 21 patients with SC (age (SD)=73.2 (5.2), m/f=13/8; 7 ApoE epsilon4 carriers) for this study. Resting state EEGs were recorded in all subjects. Synchronisation likelihood (SL) between local cortical areas was compared in the alpha and beta band according to ApoE epsilon4 status and diagnosis. RESULTS: ApoE epsilon4 carriers had higher SL values in lower and upper alpha band, in both diagnostic groups. In upper alpha band and beta band AD patients had lower SL than patients with SC, was irrespective of ApoE status. CONCLUSION: The effects of AD and ApoE epsilon4 on functional connectivity are opposite and independent. SIGNIFICANCE: The observed increase in SL in both AD and patients with SC carrying ApoE epsilon4 suggests a strong genetic impact of ApoE epsilon4 on brain function.
OBJECTIVE: We examined the relation between Apolipoprotein E epsilon4 allele (ApoE epsilon4) genotype and functional connectivity measured by Electroencephalography (EEG) in patients with Alzheimer's disease (AD) and patients with subjective complaints (SC). METHODS: We included 43 patients with AD (age (SD)=74.2 (4.0), m/f=22/21; 30 of ApoE epsilon4 carriers) and 21 patients with SC (age (SD)=73.2 (5.2), m/f=13/8; 7 ApoE epsilon4 carriers) for this study. Resting state EEGs were recorded in all subjects. Synchronisation likelihood (SL) between local cortical areas was compared in the alpha and beta band according to ApoE epsilon4 status and diagnosis. RESULTS:ApoE epsilon4 carriers had higher SL values in lower and upper alpha band, in both diagnostic groups. In upper alpha band and beta band ADpatients had lower SL than patients with SC, was irrespective of ApoE status. CONCLUSION: The effects of AD and ApoE epsilon4 on functional connectivity are opposite and independent. SIGNIFICANCE: The observed increase in SL in both AD and patients with SC carrying ApoE epsilon4 suggests a strong genetic impact of ApoE epsilon4 on brain function.
Authors: Loes Koelewijn; Thomas M Lancaster; David Linden; Diana C Dima; Bethany C Routley; Lorenzo Magazzini; Kali Barawi; Lisa Brindley; Rachael Adams; Katherine E Tansey; Aline Bompas; Andrea Tales; Antony Bayer; Krish Singh Journal: Elife Date: 2019-04-30 Impact factor: 8.140
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Authors: Willem de Haan; Yolande A L Pijnenburg; Rob L M Strijers; Yolande van der Made; Wiesje M van der Flier; Philip Scheltens; Cornelis J Stam Journal: BMC Neurosci Date: 2009-08-21 Impact factor: 3.288
Authors: Willem de Haan; Katherine Mott; Elisabeth C W van Straaten; Philip Scheltens; Cornelis J Stam Journal: PLoS Comput Biol Date: 2012-08-16 Impact factor: 4.475