| Literature DB >> 18848780 |
Payare L Sangwan1, Jawahir L Koul, Surrinder Koul, Mallepally V Reddy, Niranjan Thota, Inshad A Khan, Ashwani Kumar, Nitin P Kalia, Ghulam N Qazi.
Abstract
Based on our recent findings that piperine is a potent Staphylococcus aureus NorA efflux pump inhibitor (EPI), 38 piperine analogs were synthesized and bioevaluated for their EPI activity. Twenty-five of them were found active with potentiating activity equivalent or more than known EPIs like reserpine, carsonic acid and verapamil. The inhibitory mechanism of the compounds was confirmed by efflux inhibition assay using ethidium bromide as NorA substrate. The present communication describes the synthesis, bioevaluation and structure related activity of these efflux pump inhibitors.Entities:
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Year: 2008 PMID： 18848780 DOI： 10.1016/j.bmc.2008.09.042
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641