Literature DB >> 18848638

Immunogenicity of orally-delivered lipid-formulated BCG vaccines and protection against Mycobacterium tuberculosis infection.

Julia Vipond1, Martin L Cross, Matthew R Lambeth, Simon Clark, Frank E Aldwell, Ann Williams.   

Abstract

Lipid formulations containing BCG strains Danish 1331 or Moreau (Rio de Janeiro) were trialled as oral vaccines in rodent models. In mice, oral-delivery of either strain resulted in BCG colonisation of the alimentary tract lymphatics and induction of gamma-interferon responses. In guinea pigs, both strains provided pulmonary protection against Mycobacterium tuberculosis aerosol challenge, as shown by significantly reduced bacterial loads and lung:body weight ratios. Lipid-formulated BCG provided superior protection against M. tuberculosis over unformulated orally-delivered BCG (Moreau), and equivalent protection to sub-cutaneous BCG (Danish) immunisation. Oral-delivery of lipid-formulated BCG may offer a practical alternative to parenteral-route BCG vaccination.

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Year:  2008        PMID： 18848638     DOI： 10.1016/j.micinf.2008.09.004

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  6 in total

Review 1.  Prospects in Mycobacterium bovis Bacille Calmette et Guérin (BCG) vaccine diversity and delivery: why does BCG fail to protect against tuberculosis?

Authors:  Juan I Moliva; Joanne Turner; Jordi B Torrelles
Journal:  Vaccine       Date:  2015-08-28       Impact factor: 3.641

Review 2.  Recombinant Mycobacterium bovis BCG as an HIV vaccine vector.

Authors:  Rosamund Chapman; Gerald Chege; Enid Shephard; Helen Stutz; Anna-Lise Williamson
Journal:  Curr HIV Res       Date:  2010-06       Impact factor: 1.581

3.  Oral bacillus Calmette-Guérin vaccine against tuberculosis: why not?

Authors:  Renata Monteiro-Maia; Rosa Teixeira de Pinho
Journal:  Mem Inst Oswaldo Cruz       Date:  2014-09       Impact factor: 2.743

4.  The Effect of Oral Vaccination with Mycobacterium bovis BCG on the Development of Tuberculosis in Captive European Badgers (Meles meles).

Authors:  Mark A Chambers; Frank Aldwell; Gareth A Williams; Si Palmer; Sonya Gowtage; Roland Ashford; Deanna J Dalley; Dipesh Davé; Ute Weyer; Francisco J Salguero; Alejandro Nunez; Allan K Nadian; Timothy Crawshaw; Leigh A L Corner; Sandrine Lesellier
Journal:  Front Cell Infect Microbiol       Date:  2017-01-24       Impact factor: 5.293

5.  Detection of live M. bovis BCG in tissues and IFN-γ responses in European badgers (Meles meles) vaccinated by oropharyngeal instillation or directly in the ileum.

Authors:  Sandrine Lesellier; Maria-Laura Boschiroli; Jacques Barrat; Christoph Wanke; Francisco J Salguero; Waldo L Garcia-Jimenez; Alex Nunez; Ana Godinho; John Spiropoulos; Simonette Palmer; Dipesh Dave; Paul Anderson; Jean-Marc Boucher; Krystel de Cruz; Sylvie Henault; Lorraine Michelet; Sonya Gowtage; Gareth A Williams; Allan K Nadian; Elodie Monchâtre-Leroy; Frank Boué; Mark A Chambers; Céline Richomme
Journal:  BMC Vet Res       Date:  2019-12-06       Impact factor: 2.741

6.  Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response.

Authors:  Lindsay R Ancelet; Frank E Aldwell; Fenella J Rich; Joanna R Kirman
Journal:  PLoS One       Date:  2012-09-25       Impact factor: 3.240
  6 in total

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