Literature DB >> 18846341

The expression of integrinbeta1 and FAK in pituitary adenomas and their correlation with invasiveness.

Feng Wang1, Kai Shu, Ting Lei, Delin Xue.   

Abstract

The expression and possible role of integrin-focal adhesion kinase signal pathway in invasive pituitary adenomas were explored. Forty-nine human pituitary adenomas were detected for the expression of integrinbeta1 (INTbeta1) and focal adhesion kinase (FAK) by immunohistochemistry, and their correlation with the invasiveness of pituitary adenomas as well as between themselves was analyzed. The results showed that INTbeta1 was expressed in 46 cases (93.9%) and FAK in 36 cases (73.5%), respectively, and their expression levels were highly correlated with tumor invasiveness, but not with the tumor types. It was suggested that the integrin-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas.

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Year:  2008        PMID： 18846341     DOI： 10.1007/s11596-008-0518-6

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  15 in total

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2.  INVASIVE PITUITARY ADENOMAS.

Authors:  A N MARTINS; G J HAYES; L G KEMPE
Journal:  J Neurosurg       Date:  1965-03       Impact factor: 5.115

3.  Adenomatous transformation of the human anterior pituitary is associated with alterations in integrin expression.

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Review 8.  PTEN gene and integrin signaling in cancer.

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Review 4.  The Microenvironment of Pituitary Tumors-Biological and Therapeutic Implications.

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5.  Quantitative Analysis of Proteome in Non-functional Pituitary Adenomas: Clinical Relevance and Potential Benefits for the Patients.

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  6 in total

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