Literature DB >> 18845487

The effects of IL-6 on CD4 T cell responses.

Oliver Dienz1, Mercedes Rincon.   

Abstract

Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases.

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Year:  2008        PMID： 18845487      PMCID： PMC2660866          DOI： 10.1016/j.clim.2008.08.018

Source DB:  PubMed          Journal:  Clin Immunol        ISSN： 1521-6616            Impact factor:   3.969


  61 in total

1.  Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.

Authors:  Chandrashekhar Pasare; Ruslan Medzhitov
Journal:  Science       Date:  2003-01-16       Impact factor: 47.728

2.  Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.

Authors:  R Atreya; J Mudter; S Finotto; J Müllberg; T Jostock; S Wirtz; M Schütz; B Bartsch; M Holtmann; C Becker; D Strand; J Czaja; J F Schlaak; H A Lehr; F Autschbach; G Schürmann; N Nishimoto; K Yoshizaki; H Ito; T Kishimoto; P R Galle; S Rose-John; M F Neurath
Journal:  Nat Med       Date:  2000-05       Impact factor: 53.440

3.  Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1.

Authors:  Sean Diehl; J Anguita; A Hoffmeyer; T Zapton; J N Ihle; E Fikrig; M Rincón
Journal:  Immunity       Date:  2000-12       Impact factor: 31.745

4.  Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.

Authors:  T Jostock; J Müllberg; S Ozbek; R Atreya; G Blinn; N Voltz; M Fischer; M F Neurath; S Rose-John
Journal:  Eur J Biochem       Date:  2001-01

Review 5.  Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

Authors:  Peter C Heinrich; Iris Behrmann; Serge Haan; Heike M Hermanns; Gerhard Müller-Newen; Fred Schaper
Journal:  Biochem J       Date:  2003-08-15       Impact factor: 3.857

6.  A critical role for IL-21 in regulating immunoglobulin production.

Authors:  Katsutoshi Ozaki; Rosanne Spolski; Carl G Feng; Chen-Feng Qi; Jun Cheng; Alan Sher; Herbert C Morse; Chengyu Liu; Pamela L Schwartzberg; Warren J Leonard
Journal:  Science       Date:  2002-11-22       Impact factor: 47.728

7.  Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.

Authors:  Kenji Ichiyama; Hideyuki Yoshida; Yu Wakabayashi; Takatoshi Chinen; Kazuko Saeki; Mako Nakaya; Giichi Takaesu; Shohei Hori; Akihiko Yoshimura; Takashi Kobayashi
Journal:  J Biol Chem       Date:  2008-04-23       Impact factor: 5.157

8.  Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.

Authors:  Martin J Boulanger; Dar-chone Chow; Elena E Brevnova; K Christopher Garcia
Journal:  Science       Date:  2003-06-27       Impact factor: 47.728

9.  Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.

Authors:  Andrea L Wurster; Vikki L Rodgers; Abhay R Satoskar; Matthew J Whitters; Deborah A Young; Mary Collins; Michael J Grusby
Journal:  J Exp Med       Date:  2002-10-07       Impact factor: 14.307

10.  Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation.

Authors:  Sean Diehl; Chi-Wing Chow; Linda Weiss; Alois Palmetshofer; Thomas Twardzik; Laura Rounds; Edgar Serfling; Roger J Davis; Juan Anguita; Mercedes Rincón
Journal:  J Exp Med       Date:  2002-07-01       Impact factor: 14.307
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  181 in total

1.  IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma.

Authors:  Naeun Lee; Sungyong You; Min Sun Shin; Won-Woo Lee; Ki Soo Kang; Sang Hyun Kim; Wan-Uk Kim; Robert J Homer; Min-Jong Kang; Ruth R Montgomery; Charles S Dela Cruz; Albert C Shaw; Patty J Lee; Geoffrey L Chupp; Daehee Hwang; Insoo Kang
Journal:  Am J Respir Crit Care Med       Date:  2014-12-15       Impact factor: 21.405

2.  Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells.

Authors:  Birgit Fogal; Tai Yi; Chen Wang; Deepak A Rao; Amir Lebastchi; Sanjay Kulkarni; George Tellides; Jordan S Pober
Journal:  J Immunol       Date:  2011-11-14       Impact factor: 5.422

3.  Cytokine expression and accelerated tooth movement.

Authors:  C C Teixeira; E Khoo; J Tran; I Chartres; Y Liu; L M Thant; I Khabensky; L P Gart; G Cisneros; M Alikhani
Journal:  J Dent Res       Date:  2010-07-16       Impact factor: 6.116

4.  Pretreatment levels of soluble cellular receptors and interleukin-6 are associated with HIV disease progression in subjects treated with highly active antiretroviral therapy.

Authors:  Robert C Kalayjian; Rhoderick N Machekano; Nesrine Rizk; Gregory K Robbins; Rajesh T Gandhi; Benigno A Rodriguez; Richard B Pollard; Michael M Lederman; Alan Landay
Journal:  J Infect Dis       Date:  2010-06-15       Impact factor: 5.226

5.  Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.

Authors:  Roshni Srivastava; Jiasheng Zhang; Gwang-Woong Go; Anand Narayanan; Timothy P Nottoli; Arya Mani
Journal:  Cell Rep       Date:  2015-10-17       Impact factor: 9.423

6.  Identification and validation of shrimp-tropomyosin specific CD4 T cell epitopes.

Authors:  Eugene V Ravkov; Igor Y Pavlov; Thomas B Martins; Gerald J Gleich; Lori A Wagner; Harry R Hill; Julio C Delgado
Journal:  Hum Immunol       Date:  2013-08-28       Impact factor: 2.850

7.  FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells.

Authors:  Min Zhu; Qing-Jun Zhang; Lin Wang; Hao Li; Zhi-Ping Liu
Journal:  Atherosclerosis       Date:  2011-10-02       Impact factor: 5.162

8.  Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.

Authors:  Lindsay L Jones; Rajshekhar Alli; Bofeng Li; Terrence L Geiger
Journal:  J Immunol       Date:  2016-02-24       Impact factor: 5.422

9.  The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice.

Authors:  Di Wang; Qian Li; Yidi Qu; Mengya Wang; Lanzhou Li; Yang Liu; Yu Li
Journal:  Exp Ther Med       Date:  2018-01-30       Impact factor: 2.447

Review 10.  Cytokines and T-Cell Homeostasis in HIV Infection.

Authors:  Michael L Freeman; Carey L Shive; Thao P Nguyen; Souheil-Antoine Younes; Soumya Panigrahi; Michael M Lederman
Journal:  J Infect Dis       Date:  2016-10-01       Impact factor: 5.226
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