| Literature DB >> 18845435 |
Christian O Janssen1, Stephanie Lim, Ee Peng Lo, Kah Fei Wan, Victor C Yu, May Ann Lee, Siew Bee Ng, Martin J Everett, Antony D Buss, David P Lane, Rustum S Boyce.
Abstract
The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding.Entities:
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Year: 2008 PMID： 18845435 DOI： 10.1016/j.bmcl.2008.09.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823