Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats.

The present study was undertaken to evaluate the preventive role of naringin on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione). ISO-induction also showed a significant increase in the levels of mitochondrial cholesterol, triglycerides and free fatty acids with a subsequent decrease in the levels of phospholipids. Oral pretreatment with naringin (10, 20 and 40 mg/kg) to ISO-induced rats daily for a period of 56 days significantly decreased the levels of mitochondrial lipid peroxides with a significant increase in the activities/levels of mitochondrial antioxidants and significantly minimized the alterations in the mitochondrial lipid levels in ISO-induced rats. Thus, the findings demonstrate that naringin prevents alterations in mitochondrial lipid peroxides, antioxidants and lipids in ISO-induced MI in rats. (c) 2008 John Wiley & Sons, Ltd.