| Literature DB >> 18844286 |
Caterina Scuderi1, Daniele De Filippis, Teresa Iuvone, Angelo Blasio, Antonio Steardo, Giuseppe Esposito.
Abstract
Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders.Entities:
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Year: 2009 PMID： 18844286 DOI： 10.1002/ptr.2625
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878