| Literature DB >> 18843527 |
Seyed Mohammad Akrami1, Vahideh Montazeri, Somaieh Rashid Shomali, Ramin Heshmat, Bagher Larijani.
Abstract
Consanguineous marriage is a common practice in Iran. The present study surveyed the trend in consanguineous marriage across three generations of Iranians. Index cases, consisting of 400 individuals attending the diabetes and osteoporosis clinic in Shariati Hospital, were interviewed. Data on consanguinity status for 1789 marriages within the index cases' families were obtained. Generation 1 consisted of marriages contracted before 1948, Generation 2 consisted of marriages contracted between 1949 and 1978, and Generation 3 consisted of marriages contracted after 1979. Prevalence of consanguineous marriage within these three generations was 8.8%, 16.6% and 19%, respectively, and represented a significant trend (p < 0.001). First cousin marriage was the most common type of consanguinity (69%). Socioeconomic level of families was not significantly related to having a consanguineous marriage. These data suggest that premarital genetic counseling and mass media efforts are needed to increase public awareness about genetic risks associated with consanguineous marriage.Entities:
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Year: 2008 PMID： 18843527 DOI： 10.1007/s10897-008-9191-y
Source DB: PubMed Journal: J Genet Couns ISSN： 1059-7700 Impact factor: 2.537