STUDY OBJECTIVES: The purpose of this study was to determine if asthma with rhinitis and asthma without rhinitis represent distinct forms of disease. DESIGN: We performed a prospective cross-sectional study. PARTICIPANTS: The study included healthy controls, participants with asthma without rhinitis, and participants with both asthma and rhinitis. Interventions We compared lung function and airway inflammation between the three groups of participants. RESULTS: We recruited 32 participants: 12 normals, 8 asthmatics without rhinitis, and 12 with rhinitis. Compared to asthmatics with rhinitis, asthmatics without rhinitis had more severe airflow limitation (FEV(1)/FVC = 60.6% [IQR = 22.8] vs. 74.8% [IQR = 7.8] and fewer induced sputum eosinophils (2.8 [IQR = 5.8] and 9.6 [IQR = 23.8], respectively). Sputum interleukin-6 correlated inversely with lung function measured by postbronchodilator FEV(1) in the study cohort (Spearman correlation coefficient = -0.55, p < 0.01). CONCLUSIONS: Asthmatics without rhinitis tend to have lower lung function and less eosinophilic inflammation in the lung. This small study suggests that asthmatics without rhinitis represent a distinct phenotype of asthma in which low lung function is dissociated from eosinophilic cellular inflammation, and it suggests that larger studies addressing this phenotype are warrented.
STUDY OBJECTIVES: The purpose of this study was to determine if asthma with rhinitis and asthma without rhinitis represent distinct forms of disease. DESIGN: We performed a prospective cross-sectional study. PARTICIPANTS: The study included healthy controls, participants with asthma without rhinitis, and participants with both asthma and rhinitis. Interventions We compared lung function and airway inflammation between the three groups of participants. RESULTS: We recruited 32 participants: 12 normals, 8 asthmatics without rhinitis, and 12 with rhinitis. Compared to asthmatics with rhinitis, asthmatics without rhinitis had more severe airflow limitation (FEV(1)/FVC = 60.6% [IQR = 22.8] vs. 74.8% [IQR = 7.8] and fewer induced sputum eosinophils (2.8 [IQR = 5.8] and 9.6 [IQR = 23.8], respectively). Sputum interleukin-6 correlated inversely with lung function measured by postbronchodilator FEV(1) in the study cohort (Spearman correlation coefficient = -0.55, p < 0.01). CONCLUSIONS: Asthmatics without rhinitis tend to have lower lung function and less eosinophilic inflammation in the lung. This small study suggests that asthmatics without rhinitis represent a distinct phenotype of asthma in which low lung function is dissociated from eosinophilic cellular inflammation, and it suggests that larger studies addressing this phenotype are warrented.
Authors: R O Crapo; R Casaburi; A L Coates; P L Enright; J L Hankinson; C G Irvin; N R MacIntyre; R T McKay; J S Wanger; S D Anderson; D W Cockcroft; J E Fish; P J Sterk Journal: Am J Respir Crit Care Med Date: 2000-01 Impact factor: 21.405
Authors: G J Braunstahl; A Kleinjan; S E Overbeek; J B Prins; H C Hoogsteden; W J Fokkens Journal: Am J Respir Crit Care Med Date: 2000-06 Impact factor: 21.405
Authors: M Gaga; P Lambrou; N Papageorgiou; N G Koulouris; E Kosmas; S Fragakis; C Sofios; A Rasidakis; J Jordanoglou Journal: Clin Exp Allergy Date: 2000-05 Impact factor: 5.018
Authors: Anneke ten Brinke; Diana C Grootendorst; Judith Th Schmidt; Francisca T De Bruïne; Mark A van Buchem; Peter J Sterk; Klaus F Rabe; Elisabeth H Bel Journal: J Allergy Clin Immunol Date: 2002-04 Impact factor: 10.793
Authors: Anne E Dixon; Mario Castro; Lynn B Gerald; Janet T Holbrook; Robert J Henderson; Thomas B Casale; Charles G Irvin; Kendall Black; Robert A Wise; Elizabeth A Sugar Journal: J Allergy Clin Immunol Pract Date: 2017-04-07
Authors: Wendy A Neveu; Jenna L Allard; Danielle M Raymond; Lorraine M Bourassa; Stephanie M Burns; Janice Y Bunn; Charles G Irvin; David A Kaminsky; Mercedes Rincon Journal: Respir Res Date: 2010-03-08