Literature DB >> 18843415

PNA based artificial nucleases displaying catalysis with turnover in the cleavage of a leukemia related RNA model.

Merita Murtola1, Roger Strömberg.   

Abstract

Several peptide nucleic acid based artificial nucleases (PNAzymes) are designed to create a bulge in the target RNA, which is a short model of the leukemia related bcr/abl mRNA. The target RNA is cleaved by the PNAzymes with a half-life of down to 11 h (using a 1 : 1 ratio of PNA-conjugate to target) and only upon base-pairing with the substrate. The PNA based systems are also shown to act in a catalytic fashion with turnover of substrate and are thus the first reported peptide nucleic acid based artificial RNA-cleaving enzymes.

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Year:  2008        PMID： 18843415     DOI： 10.1039/b810106j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  "Bind, cleave and leave": multiple turnover catalysis of RNA cleavage by bulge-loop inducing supramolecular conjugates.

Authors:  Bahareh Amirloo; Yaroslav Staroseletz; Sameen Yousaf; David J Clarke; Tom Brown; Harmesh Aojula; Marina A Zenkova; Elena V Bichenkova
Journal:  Nucleic Acids Res       Date:  2022-01-25       Impact factor: 16.971

2.  Photoswitching of site-selective RNA scission by sequential incorporation of azobenzene and acridine residues in a DNA oligomer.

Authors:  Akinori Kuzuya; Keita Tanaka; Makoto Komiyama
Journal:  J Nucleic Acids       Date:  2011-09-21

3.  An activated triple bond linker enables 'click' attachment of peptides to oligonucleotides on solid support.

Authors:  Malgorzata Wenska; Margarita Alvira; Peter Steunenberg; Asa Stenberg; Merita Murtola; Roger Strömberg
Journal:  Nucleic Acids Res       Date:  2011-07-27       Impact factor: 16.971

4.  Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole).

Authors:  Friederike Danneberg; Alice Ghidini; Plamena Dogandzhiyski; Elisabeth Kalden; Roger Strömberg; Michael W Göbel
Journal:  Beilstein J Org Chem       Date:  2015-04-16       Impact factor: 2.883

5.  Influence of sequence variation on the RNA cleavage activity of Zn2+-dimethyl-dppz-PNA-based artificial enzymes.

Authors:  Olivia Luige; Kristina Karalė; Partha Pratim Bose; Martin Bollmark; Ulf Tedebark; Merita Murtola; Roger Strömberg
Journal:  RSC Adv       Date:  2022-02-14       Impact factor: 3.361

6.  Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA-Bulge Size and Sequence Dependence.

Authors:  Merita Murtola; Alice Ghidini; Pasi Virta; Roger Strömberg
Journal:  Molecules       Date:  2017-10-29       Impact factor: 4.411
  6 in total

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