Literature DB >> 18843269

Metabolomics: a global biochemical approach to the study of central nervous system diseases.

Rima Kaddurah-Daouk1, K Ranga Rama Krishnan.   

Abstract

Metabolomics, the omics science of biochemistry, is a global approach to understanding regulation of metabolic pathways and metabolic networks of a biological system. Metabolomics complements data derived from genomics, transcriptomics, and proteomics to assist in providing a systems approach to the study of human health and disease. In this review we focus on applications of metabolomics for the study of diseases of the nervous system. We share concepts in metabolomics, tools used in metabolic profiling and early findings from the study of neuropsychiatric diseases, and drugs used to treat these diseases. Metabolomics emerges as another powerful tool in central nervous system research.

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Year:  2008        PMID： 18843269     DOI： 10.1038/npp.2008.174

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


  103 in total

1.  3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia.

Authors:  Ruth Condray; George G Dougherty; Matcheri S Keshavan; Ravinder D Reddy; Gretchen L Haas; Debra M Montrose; Wayne R Matson; Joseph McEvoy; Rima Kaddurah-Daouk; Jeffrey K Yao
Journal:  Int J Neuropsychopharmacol       Date:  2011-01-28       Impact factor: 5.176

Review 2.  Integration of metabolic reactions and gene regulation.

Authors:  Chen-Hsiang Yeang
Journal:  Mol Biotechnol       Date:  2011-01       Impact factor: 2.695

3.  Metabolomic changes in autopsy-confirmed Alzheimer's disease.

Authors:  Rima Kaddurah-Daouk; Steve Rozen; Wayne Matson; Xianlin Han; Christine M Hulette; James R Burke; P Murali Doraiswamy; Kathleen A Welsh-Bohmer
Journal:  Alzheimers Dement       Date:  2010-11-13       Impact factor: 21.566

Review 4.  Postgenomics diagnostics: metabolomics approaches to human blood profiling.

Authors:  Oxana Trifonova; Petr Lokhov; Alexander Archakov
Journal:  OMICS       Date:  2013-09-17

5.  Metabolomic differences in heart failure patients with and without major depression.

Authors:  David C Steffens; K Ranga R Krishnan; Edward D Karoly; Matthew W Mitchell; Christopher M O'Connor; Rima Kaddurah-Daouk
Journal:  J Geriatr Psychiatry Neurol       Date:  2010-01-25       Impact factor: 2.680

Review 6.  Blood-based protein biomarkers for diagnosis and classification of neurodegenerative diseases: current progress and clinical potential.

Authors:  Carmen Noelker; Harald Hampel; Richard Dodel
Journal:  Mol Diagn Ther       Date:  2011-04-01       Impact factor: 4.074

7.  Profiling of lipidomics before and after antipsychotic treatment in first-episode psychosis.

Authors:  Liisa Leppik; Madis Parksepp; Sven Janno; Kati Koido; Liina Haring; Eero Vasar; Mihkel Zilmer
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2019-01-02       Impact factor: 5.270

Review 8.  Human brain evolution: transcripts, metabolites and their regulators.

Authors:  Mehmet Somel; Xiling Liu; Philipp Khaitovich
Journal:  Nat Rev Neurosci       Date:  2013-01-17       Impact factor: 34.870

9.  Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.

Authors:  P Matthew Joyner; Ronni M Matheke; Lindsey M Smith; Robert H Cichewicz
Journal:  J Proteome Res       Date:  2010-01       Impact factor: 4.466

Review 10.  Biomarkers to predict antidepressant response.

Authors:  Andrew F Leuchter; Ian A Cook; Steven P Hamilton; Katherine L Narr; Arthur Toga; Aimee M Hunter; Kym Faull; Julian Whitelegge; Anne M Andrews; Joseph Loo; Baldwin Way; Stanley F Nelson; Steven Horvath; Barry D Lebowitz
Journal:  Curr Psychiatry Rep       Date:  2010-12       Impact factor: 5.285
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