BACKGROUND: Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. METHODS: From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. RESULTS: A history of any major surgery, conducted >/=20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95% CI = 1.46-4.07) and unmatched controls (OR = 2.25, 95% CI = 1.48-3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95% CI = 1.13-2.18; OR = 1.50, 95% CI = 1.18-1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. CONCLUSIONS: A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission. Copyright 2008 S. Karger AG, Basel.
BACKGROUND: Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. METHODS: From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. RESULTS: A history of any major surgery, conducted >/=20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95% CI = 1.46-4.07) and unmatched controls (OR = 2.25, 95% CI = 1.48-3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95% CI = 1.13-2.18; OR = 1.50, 95% CI = 1.18-1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. CONCLUSIONS: A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission. Copyright 2008 S. Karger AG, Basel.
Authors: I Zerr; J P Brandel; C Masullo; D Wientjens; R de Silva; M Zeidler; E Granieri; S Sampaolo; C van Duijn; N Delasnerie-Lauprêtre; R Will; S Poser Journal: J Clin Epidemiol Date: 2000-07 Impact factor: 6.437
Authors: I Zerr; M Pocchiari; S Collins; J P Brandel; J de Pedro Cuesta; R S Knight; H Bernheimer; F Cardone; N Delasnerie-Lauprêtre; N Cuadrado Corrales; A Ladogana; M Bodemer; A Fletcher; T Awan; A Ruiz Bremón; H Budka; J L Laplanche; R G Will; S Poser Journal: Neurology Date: 2000-09-26 Impact factor: 9.910
Authors: P Brown; M Preece; J P Brandel; T Sato; L McShane; I Zerr; A Fletcher; R G Will; M Pocchiari; N R Cashman; J H d'Aignaux; L Cervenáková; J Fradkin; L B Schonberger; S J Collins Journal: Neurology Date: 2000-10-24 Impact factor: 9.910
Authors: H J T Ward; D Everington; E A Croes; A Alperovitch; N Delasnerie-Lauprêtre; I Zerr; S Poser; C M van Duijn Journal: Neurology Date: 2002-08-27 Impact factor: 9.910
Authors: Julie Ann Edgeworth; Graham S Jackson; Anthony R Clarke; Charles Weissmann; John Collinge Journal: Proc Natl Acad Sci U S A Date: 2009-02-09 Impact factor: 11.205
Authors: Helen M J Klemm; Jeremy M Welton; Colin L Masters; Genevieve M Klug; Alison Boyd; Andrew F Hill; Steven J Collins; Victoria A Lawson Journal: J Biol Chem Date: 2012-08-28 Impact factor: 5.157
Authors: Matt Stevenson; Lesley Uttley; Jeremy E Oakley; Christopher Carroll; Stephen E Chick; Ruth Wong Journal: Health Technol Assess Date: 2020-02 Impact factor: 4.014
Authors: Mercedes Muñoz-Nieto; Neus Ramonet; Juan Ignacio López-Gastón; Natividad Cuadrado-Corrales; Olga Calero; Marcos Díaz-Hurtado; José Ramón Ipiens; Santiago Ramón y Cajal; Jesús de Pedro-Cuesta; Miguel Calero Journal: J Neurol Date: 2012-07-05 Impact factor: 4.849
Authors: Julie Ann Edgeworth; Anita Sicilia; Jackie Linehan; Sebastian Brandner; Graham S Jackson; John Collinge Journal: J Gen Virol Date: 2010-11-17 Impact factor: 3.891