| Literature DB >> 1884247 |
H Kawasaki1, H Kuwabara, H Hori, M Higashigawa, T Ohkubo, M Sakurai.
Abstract
In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.Entities:
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Year: 1991 PMID： 1884247 DOI： 10.3109/07357909109084638
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176