| Literature DB >> 18841911 |
Sonia A van der Sar1, Gerhard Lang, Maya I Mitova, John W Blunt, Anthony L J Cole, Nicholas Cummings, Gill Ellis, Murray H G Munro.
Abstract
Biosynthetic studies on spiro-mamakone A (1), a potently cytotoxic and antimicrobial compound from an endophytic fungus isolated from the New Zealand native tree Knightia excelsa (rewarewa), confirm the polyketide origins of this unique compound belonging to the spirobisnaphthalene class of compounds. The biosynthesis proceeds via an unprecedented symmetric enedione with the two halves of the molecule being formed from two separate pentaketide units connected by oxidative coupling.Entities:
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Year: 2008 PMID： 18841911 DOI： 10.1021/jo801564c
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354