M Ishizuka1, H Nagata, K Takagi, K Kubota. 1. Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan. mm-ishizuka@umin.ac.jp
Abstract
PURPOSE: To clarify the risk factors for central venous catheter-related bloodstream infection (CVCR-BSI) in patients receiving chemotherapy after surgery for colorectal cancer (CRC). METHODS: CVCR-BSI was evaluated retrospectively from a database of patients who had received postoperative chemotherapy using central venous catheters (CVC). RESULTS: One hundred and nine patients received 542 CVC for a total of 5,558 catheter-days. There were no significant differences in background between the patients who had CVCR-BSI and those who did not, except for the administration of total parenteral nutrition (TPN) (p < 0.0001). Moreover, univariate analyses (using factors including type of catheter, sex, age, troubles with insertion, kinds of disinfectant, kinds of catheter, length of inserted catheter, term of catheter insertion and administration of TPN) revealed that the administration of TPN (odds ratio, 12.74; 95% CI, 2.489-62.26; p = 0.0023) was the only risk factor for CVCR-BSI. CONCLUSIONS: TPN is a major risk factor for CVCR-BSI in CRC patients receiving postoperative chemotherapy. (c) 2008 S. Karger AG, Basel.
PURPOSE: To clarify the risk factors for central venous catheter-related bloodstream infection (CVCR-BSI) in patients receiving chemotherapy after surgery for colorectal cancer (CRC). METHODS: CVCR-BSI was evaluated retrospectively from a database of patients who had received postoperative chemotherapy using central venous catheters (CVC). RESULTS: One hundred and nine patients received 542 CVC for a total of 5,558 catheter-days. There were no significant differences in background between the patients who had CVCR-BSI and those who did not, except for the administration of total parenteral nutrition (TPN) (p < 0.0001). Moreover, univariate analyses (using factors including type of catheter, sex, age, troubles with insertion, kinds of disinfectant, kinds of catheter, length of inserted catheter, term of catheter insertion and administration of TPN) revealed that the administration of TPN (odds ratio, 12.74; 95% CI, 2.489-62.26; p = 0.0023) was the only risk factor for CVCR-BSI. CONCLUSIONS: TPN is a major risk factor for CVCR-BSI in CRC patients receiving postoperative chemotherapy. (c) 2008 S. Karger AG, Basel.
Authors: Melissa A Hull; Brian A Jones; David Zurakowski; Bram Raphael; Clifford Lo; Tom Jaksic; Christopher Duggan Journal: JPEN J Parenter Enteral Nutr Date: 2011-03 Impact factor: 4.016
Authors: Amanda J Ullman; Marie L Cooke; Donna Gillies; Nicole M Marsh; Azlina Daud; Matthew R McGrail; Elizabeth O'Riordan; Claire M Rickard Journal: Cochrane Database Syst Rev Date: 2013-09-15