| Literature DB >> 18840734 |
Mônica da Silva-Nunes1, Vanda A F de Souza, Cláudio S Pannuti, Márcia A Sperança, Ana Carolina B Terzian, Maurício L Nogueira, Anna M Y Yamamura, Marcos S Freire, Natal S da Silva, Rosely S Malafronte, Pascoal T Muniz, Helena B Vasconcelos, Eliana V P da Silva, Pedro F C Vasconcelos, Marcelo U Ferreira.
Abstract
A comparison of dengue virus (DENV) antibody levels in paired serum samples collected from predominantly DENV-naive residents in an agricultural settlement in Brazilian Amazonia (baseline seroprevalence, 18.3%) showed a seroconversion rate of 3.67 episodes/100 person-years at risk during 12 months of follow-up. Multivariate analysis identified male sex, poverty, and migration from extra-Amazonian states as significant predictors of baseline DENV seropositivity, whereas male sex, a history of clinical diagnosis of dengue fever, and travel to an urban area predicted subsequent seroconversion. The laboratory surveillance of acute febrile illnesses implemented at the study site and in a nearby town between 2004 and 2006 confirmed 11 DENV infections among 102 episodes studied with DENV IgM detection, reverse transcriptase-polymerase chain reaction, and virus isolation; DENV-3 was isolated. Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population.Entities:
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Year: 2008 PMID： 18840734
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345