OBJECTIVE: To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosisafter total hip replacement. DESIGN: Prospective, randomised, double blind placebo controlled trial. SETTING: Winford Orthopaedic Hospital, Bristol. SUBJECTS:148 patients having primary total hip replacement. INTERVENTION: Warfarin 1 mg given daily for one week before and three weeks after surgery. MAIN OUTCOME MEASURE: Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method. RESULTS:Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%). CONCLUSION:Fixed minidosewarfarin does not prevent deep vein thrombosisafter total hip replacement.
RCT Entities:
OBJECTIVE: To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement. DESIGN: Prospective, randomised, double blind placebo controlled trial. SETTING: Winford Orthopaedic Hospital, Bristol. SUBJECTS: 148 patients having primary total hip replacement. INTERVENTION: Warfarin 1 mg given daily for one week before and three weeks after surgery. MAIN OUTCOME MEASURE: Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method. RESULTS:Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%). CONCLUSION: Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
Authors: W G Hampson; F C Harris; H K Lucas; P H Roberts; I W McCall; P C Jackson; N L Powell; G E Staddon Journal: Lancet Date: 1974-10-05 Impact factor: 79.321
Authors: J M Walenga; D Hoppensteadt; R Pifarré; N L Fox; S Forman; D B Hunninghake; L Campeau; J A Herd; B J Hoogwerf; A Hickey; J L Probstfield; M L Terrin Journal: J Thromb Thrombolysis Date: 2001-04 Impact factor: 2.300
Authors: J M Walenga; D Hoppensteadt; R Pifarré; M D Cressman; D B Hunninghake; N L Fox; M L Terrin; J L Probstfield Journal: J Thromb Thrombolysis Date: 1999-06 Impact factor: 2.300
Authors: Murray M Bern; Diane Hazel; Elizabeth Deeran; John R Richmond; Daniel M Ward; Damon J Spitz; David A Mattingly; James V Bono; Ronna H Berezin; Laura Hou; Gerald B Miley; Benjamin E Bierbaum Journal: Thromb J Date: 2015-10-07