BACKGROUND: Involvement of various gene mutations in hypertension have been already reported, including GST (detoxification Phase II enzymes), with contrasting results. This study analyzes a possible association between GSTM1-null and GSTT1-null polymorphisms and the hypertension status in a very old population (>80 years). METHODS: 354 old patients were collected (255 were hypertensive and 99 were not). RESULTS: GSTM1-null individuals (n=156) were significantly associated with increased risk of hypertension [OR=2.25 (1.36-3.72); p=0.005]. This association was confirmed both in 115 male and 239 female subjects. In contrast, no significant association was observed [p=0.52, OR=1.24 (0.67-2.29)] in the 57 hypertensive GSTT1-null genotypes vs 198 wild-type individuals. The above mentioned significances were obtained by multivariate logistic regression analysis after adjusting for confounder variables. Alcohol consumption and/or smoke habits were not significantly different between the two groups, as well as gender, marital status, education, number of concomitant diseases, and presence of cardiovascular diseases. No synergistic association was observed for the combined null genotypes of GSTT1 and GSTM1. CONCLUSIONS: The knowledge of GSTM1 variant status seems to be potentially useful to predict a possible hypertensive status after 80 years of age. This study underlines a possible importance of the GSTM1 enzyme for blood pressure regulation.
BACKGROUND: Involvement of various gene mutations in hypertension have been already reported, including GST (detoxification Phase II enzymes), with contrasting results. This study analyzes a possible association between GSTM1-null and GSTT1-null polymorphisms and the hypertension status in a very old population (>80 years). METHODS: 354 old patients were collected (255 were hypertensive and 99 were not). RESULTS:GSTM1-null individuals (n=156) were significantly associated with increased risk of hypertension [OR=2.25 (1.36-3.72); p=0.005]. This association was confirmed both in 115 male and 239 female subjects. In contrast, no significant association was observed [p=0.52, OR=1.24 (0.67-2.29)] in the 57 hypertensiveGSTT1-null genotypes vs 198 wild-type individuals. The above mentioned significances were obtained by multivariate logistic regression analysis after adjusting for confounder variables. Alcohol consumption and/or smoke habits were not significantly different between the two groups, as well as gender, marital status, education, number of concomitant diseases, and presence of cardiovascular diseases. No synergistic association was observed for the combined null genotypes of GSTT1 and GSTM1. CONCLUSIONS: The knowledge of GSTM1 variant status seems to be potentially useful to predict a possible hypertensive status after 80 years of age. This study underlines a possible importance of the GSTM1 enzyme for blood pressure regulation.
Authors: Joseph C Gigliotti; Adrienne Tin; Shirin Pourafshar; Sylvia Cechova; Yves T Wang; Sun-Sang J Sung; Gabor Bodonyi-Kovacs; Janet V Cross; Guang Yang; Nhu Nguyen; Fang Chan; Casey Rebholz; Bing Yu; Megan L Grove; Morgan E Grams; Anna Köttgen; Robert Scharpf; Phillip Ruiz; Eric Boerwinkle; Josef Coresh; Thu H Le Journal: J Am Soc Nephrol Date: 2019-11-14 Impact factor: 10.121
Authors: Jonatan R Ruiz; Carmen Fiuza-Luces; Amaya Buxens; Amalia Cano-Nieto; Félix Gómez-Gallego; Catalina Santiago; Gabriel Rodríguez-Romo; Nuria Garatachea; José I Lao; María Morán; Alejandro Lucia Journal: Age (Dordr) Date: 2011-09-06