| Literature DB >> 18839437 |
Alan H Bryce1, Rhett P Ketterling, Morie A Gertz, Martha Lacy, Ryan A Knudson, Shaji Kumar, Robert A Kyle, Rafael Fonseca, Phillip R Greipp, John A Lust, Vincent S Rajkumar, Suzanne R Hayman, Francis Buadi, Stephen J Russell, Stephen R Zeldenrust, Angela Dispenzieri.
Abstract
POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique. Copyright 2008 Wiley-Liss, Inc.Entities:
Mesh：
Year: 2008 PMID： 18839437 PMCID： PMC3956589 DOI： 10.1002/ajh.21285
Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047