BACKGROUND AND PURPOSE: It has been suggested that avascular osteonecrosis (AVN) of the femoral head develops early after renal transplantation. We evaluated the relationship between risk of AVN and dose of steroids administered in different time periods. METHODS: Development of AVN was determined using MRI at 3-6 weeks, 9-12 weeks, 24 weeks, and 12 months after transplantation in 150 patients (96 males). We investigated possible associations between acute rejection reactions, the dose of cyclosporine, tacrolimus use, total steroid dose by the second, fourth, sixth, or eighth weeks after transplantation, and incidence of AVN. RESULTS: There was no statistically significant difference between incidence of AVN and presence or absence of an acute rejection reaction. We found a statistically significant association between AVN incidence and the total dose of steroids administered during the first 2 months after transplantation, and there was a doseresponse relationship. No other statistically significant associations were found. INTERPRETATION: Our findings confirm that the total dose of steroids given within the first 2 months after renal transplantation has a great influence on the incidence of AVN.
BACKGROUND AND PURPOSE: It has been suggested that avascular osteonecrosis (AVN) of the femoral head develops early after renal transplantation. We evaluated the relationship between risk of AVN and dose of steroids administered in different time periods. METHODS: Development of AVN was determined using MRI at 3-6 weeks, 9-12 weeks, 24 weeks, and 12 months after transplantation in 150 patients (96 males). We investigated possible associations between acute rejection reactions, the dose of cyclosporine, tacrolimus use, total steroid dose by the second, fourth, sixth, or eighth weeks after transplantation, and incidence of AVN. RESULTS: There was no statistically significant difference between incidence of AVN and presence or absence of an acute rejection reaction. We found a statistically significant association between AVN incidence and the total dose of steroids administered during the first 2 months after transplantation, and there was a doseresponse relationship. No other statistically significant associations were found. INTERPRETATION: Our findings confirm that the total dose of steroids given within the first 2 months after renal transplantation has a great influence on the incidence of AVN.
Authors: Christian Powell; Christopher Chang; Stanley M Naguwa; Gurtej Cheema; M Eric Gershwin Journal: Autoimmun Rev Date: 2010-07-09 Impact factor: 9.754
Authors: Jeremy T Hines; Woo Lam Jo; Quanjun Cui; Michael A Mont; Kyung Hoi Koo; Edward Y Cheng; Stuart B Goodman; Yong Chan Ha; Phillippe Hernigou; Lynne C Jones; Shin Yoon Kim; Takashi Sakai; Nobuhiko Sugano; Takuaki Yamamoto; Mel S Lee; Dewei Zhao; Wolf Drescher; Tae Young Kim; Young Kyun Lee; Byung Ho Yoon; Seung Hoon Baek; Wataru Ando; Hong Seok Kim; Jung Wee Park Journal: J Korean Med Sci Date: 2021-06-21 Impact factor: 2.153