OBJECTIVE: Epithelioid angiomyolipoma (EAML) is a rare malignant variant of renal angiomyolipoma (AML). There were 34 cases of EAML reported in 25 studies (including this present study) over the past decade. About 68% were females and 32% males. The mean age was 40.1 years, 53% developed metastatic disease after nephrectomy, and eight patients had TSC. All cases are reported positive when stained with HMB-45 which also labels all classical AML. This study evaluates the use of Ki-67 (proliferation marker) in the pathological diagnosis of EAML and distinction from classical AML. METHOD: Immunohistochemical reactions for Ki-67 were generated on multiple representative blocks of tissue obtained from two cases of HMB-45 positive EAML and four cases of classic AML and the percentage of positively staining cells estimated. RESULTS: Both cases of EAML were strongly positive for Ki-67 while all four classic AML were completely negative. CONCLUSION: The Ki67 is a useful marker in which distinguishes the malignant epithelioid variant of AML from classic AML.
OBJECTIVE: Epithelioid angiomyolipoma (EAML) is a rare malignant variant of renal angiomyolipoma (AML). There were 34 cases of EAML reported in 25 studies (including this present study) over the past decade. About 68% were females and 32% males. The mean age was 40.1 years, 53% developed metastatic disease after nephrectomy, and eight patients had TSC. All cases are reported positive when stained with HMB-45 which also labels all classical AML. This study evaluates the use of Ki-67 (proliferation marker) in the pathological diagnosis of EAML and distinction from classical AML. METHOD: Immunohistochemical reactions for Ki-67 were generated on multiple representative blocks of tissue obtained from two cases of HMB-45 positive EAML and four cases of classic AML and the percentage of positively staining cells estimated. RESULTS: Both cases of EAML were strongly positive for Ki-67 while all four classic AML were completely negative. CONCLUSION: The Ki67 is a useful marker in which distinguishes the malignant epithelioid variant of AML from classic AML.
Authors: E P Henske; H P Neumann; B W Scheithauer; E W Herbst; M P Short; D J Kwiatkowski Journal: Genes Chromosomes Cancer Date: 1995-08 Impact factor: 5.006
Authors: Jun H Lei; Liang R Liu; Qiang Wei; Tu R Song; Lu Yang; Hai C Yuan; Yong Jiang; Huan Xu; Sheng H Xiong; Ping Han Journal: Sci Rep Date: 2015-05-05 Impact factor: 4.379