Literature DB >> 18839057

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

Klaus-Peter Lesch1, Nina Timmesfeld, Tobias J Renner, Rebecca Halperin, Christoph Röser, T Trang Nguyen, David W Craig, Jasmin Romanos, Monika Heine, Jobst Meyer, Christine Freitag, Andreas Warnke, Marcel Romanos, Helmut Schäfer, Susanne Walitza, Andreas Reif, Dietrich A Stephan, Christian Jacob.   

Abstract

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

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Year:  2008        PMID： 18839057     DOI： 10.1007/s00702-008-0119-3

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  56 in total

1.  A whole genome association study of neuroticism using DNA pooling.

Authors:  S Shifman; A Bhomra; S Smiley; N R Wray; M R James; N G Martin; J M Hettema; S S An; M C Neale; E J C G van den Oord; K S Kendler; X Chen; D I Boomsma; C M Middeldorp; J J Hottenga; P E Slagboom; J Flint
Journal:  Mol Psychiatry       Date:  2007-07-31       Impact factor: 15.992

2.  GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.

Authors:  Norio Tezuka; Anthony M C Brown; Shin-ichi Yanagawa
Journal:  Biochem Biophys Res Commun       Date:  2007-03-12       Impact factor: 3.575

3.  Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11.

Authors:  Mauricio Arcos-Burgos; F Xavier Castellanos; David Pineda; Francisco Lopera; Juan David Palacio; Luis Guillermo Palacio; Judith L Rapoport; Kate Berg; Joan E Bailey-Wilson; Maximilian Muenke
Journal:  Am J Hum Genet       Date:  2004-10-20       Impact factor: 11.025

4.  RhoA and Rac mediate endothelial cell polarization and detachment induced by T-cadherin.

Authors:  Maria Philippova; Danila Ivanov; Roy Allenspach; Yoh Takuwa; Paul Erne; Thérèse Resink
Journal:  FASEB J       Date:  2005-02-09       Impact factor: 5.191

Review 5.  "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.

Authors:  George R Uhl; Tomas Drgon; Catherine Johnson; Oluwatosin O Fatusin; Qing-Rong Liu; Carlo Contoreggi; Chuan-Yun Li; Kari Buck; John Crabbe
Journal:  Biochem Pharmacol       Date:  2007-07-25       Impact factor: 5.858

6.  CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.

Authors:  Damian M Kraus; Gary S Elliott; Hilary Chute; Thomas Horan; Karl H Pfenninger; Staci D Sanford; Stephen Foster; Sheila Scully; Andrew A Welcher; V Michael Holers
Journal:  J Immunol       Date:  2006-04-01       Impact factor: 5.422

7.  Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Authors:  Richa Saxena; Benjamin F Voight; Valeriya Lyssenko; Noël P Burtt; Paul I W de Bakker; Hong Chen; Jeffrey J Roix; Sekar Kathiresan; Joel N Hirschhorn; Mark J Daly; Thomas E Hughes; Leif Groop; David Altshuler; Peter Almgren; Jose C Florez; Joanne Meyer; Kristin Ardlie; Kristina Bengtsson Boström; Bo Isomaa; Guillaume Lettre; Ulf Lindblad; Helen N Lyon; Olle Melander; Christopher Newton-Cheh; Peter Nilsson; Marju Orho-Melander; Lennart Råstam; Elizabeth K Speliotes; Marja-Riitta Taskinen; Tiinamaija Tuomi; Candace Guiducci; Anna Berglund; Joyce Carlson; Lauren Gianniny; Rachel Hackett; Liselotte Hall; Johan Holmkvist; Esa Laurila; Marketa Sjögren; Maria Sterner; Aarti Surti; Margareta Svensson; Malin Svensson; Ryan Tewhey; Brendan Blumenstiel; Melissa Parkin; Matthew Defelice; Rachel Barry; Wendy Brodeur; Jody Camarata; Nancy Chia; Mary Fava; John Gibbons; Bob Handsaker; Claire Healy; Kieu Nguyen; Casey Gates; Carrie Sougnez; Diane Gage; Marcia Nizzari; Stacey B Gabriel; Gung-Wei Chirn; Qicheng Ma; Hemang Parikh; Delwood Richardson; Darrell Ricke; Shaun Purcell
Journal:  Science       Date:  2007-04-26       Impact factor: 47.728

8.  Genome-wide association for methamphetamine dependence: convergent results from 2 samples.

Authors:  George R Uhl; Tomas Drgon; Qing-Rong Liu; Catherine Johnson; Donna Walther; Tokutaro Komiyama; Mutsuo Harano; Yoshimoto Sekine; Toshiya Inada; Norio Ozaki; Masaomi Iyo; Nakao Iwata; Mitsuhiko Yamada; Ichiro Sora; Chih-Ken Chen; Hsing-Cheng Liu; Hiroshi Ujike; Shih-Ku Lin
Journal:  Arch Gen Psychiatry       Date:  2008-03

9.  Mice that lack astrotactin have slowed neuronal migration.

Authors:  Niels C Adams; Toshifumi Tomoda; Margaret Cooper; Gunnar Dietz; Mary E Hatten
Journal:  Development       Date:  2002-02       Impact factor: 6.868

10.  Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays.

Authors:  L M Butcher; O S P Davis; I W Craig; R Plomin
Journal:  Genes Brain Behav       Date:  2008-01-22       Impact factor: 3.449
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  165 in total

1.  Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder.

Authors:  Josephine Elia; Joseph T Glessner; Kai Wang; Nagahide Takahashi; Corina J Shtir; Dexter Hadley; Patrick M A Sleiman; Haitao Zhang; Cecilia E Kim; Reid Robison; Gholson J Lyon; James H Flory; Jonathan P Bradfield; Marcin Imielinski; Cuiping Hou; Edward C Frackelton; Rosetta M Chiavacci; Takeshi Sakurai; Cara Rabin; Frank A Middleton; Kelly A Thomas; Maria Garris; Frank Mentch; Christine M Freitag; Hans-Christoph Steinhausen; Alexandre A Todorov; Andreas Reif; Aribert Rothenberger; Barbara Franke; Eric O Mick; Herbert Roeyers; Jan Buitelaar; Klaus-Peter Lesch; Tobias Banaschewski; Richard P Ebstein; Fernando Mulas; Robert D Oades; Joseph Sergeant; Edmund Sonuga-Barke; Tobias J Renner; Marcel Romanos; Jasmin Romanos; Andreas Warnke; Susanne Walitza; Jobst Meyer; Haukur Pálmason; Christiane Seitz; Sandra K Loo; Susan L Smalley; Joseph Biederman; Lindsey Kent; Philip Asherson; Richard J L Anney; J William Gaynor; Philip Shaw; Marcella Devoto; Peter S White; Struan F A Grant; Joseph D Buxbaum; Judith L Rapoport; Nigel M Williams; Stanley F Nelson; Stephen V Faraone; Hakon Hakonarson
Journal:  Nat Genet       Date:  2011-12-04       Impact factor: 38.330

2.  Case-control genome-wide association study of attention-deficit/hyperactivity disorder.

Authors:  Benjamin M Neale; Sarah Medland; Stephan Ripke; Richard J L Anney; Philip Asherson; Jan Buitelaar; Barbara Franke; Michael Gill; Lindsey Kent; Peter Holmans; Frank Middleton; Anita Thapar; Klaus-Peter Lesch; Stephen V Faraone; Mark Daly; Thuy Trang Nguyen; Helmut Schäfer; Hans-Christoph Steinhausen; Andreas Reif; Tobias J Renner; Marcel Romanos; Jasmin Romanos; Andreas Warnke; Susanne Walitza; Christine Freitag; Jobst Meyer; Haukur Palmason; Aribert Rothenberger; Ziarih Hawi; Joseph Sergeant; Herbert Roeyers; Eric Mick; Joseph Biederman
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2010-08-05       Impact factor: 8.829

3.  Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.

Authors:  Wei Sun; Wenhua Lv; Hongchao Lv; Ruijie Zhang; Yongshuai Jiang
Journal:  Tumour Biol       Date:  2015-08-30

Review 4.  Applying imaging genetics to ADHD: the promises and the challenges.

Authors:  Zhaomin Wu; Li Yang; Yufeng Wang
Journal:  Mol Neurobiol       Date:  2014-04-01       Impact factor: 5.590

5.  Voxelwise genome-wide association study (vGWAS).

Authors:  Jason L Stein; Xue Hua; Suh Lee; April J Ho; Alex D Leow; Arthur W Toga; Andrew J Saykin; Li Shen; Tatiana Foroud; Nathan Pankratz; Matthew J Huentelman; David W Craig; Jill D Gerber; April N Allen; Jason J Corneveaux; Bryan M Dechairo; Steven G Potkin; Michael W Weiner; Paul Thompson
Journal:  Neuroimage       Date:  2010-02-17       Impact factor: 6.556

6.  Genome-wide association study of comorbid depressive syndrome and alcohol dependence.

Authors:  Alexis C Edwards; Fazil Aliev; Laura J Bierut; Kathleen K Bucholz; Howard Edenberg; Victor Hesselbrock; John Kramer; Samuel Kuperman; John I Nurnberger; Marc A Schuckit; Bernice Porjesz; Danielle M Dick
Journal:  Psychiatr Genet       Date:  2012-02       Impact factor: 2.458

7.  DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders.

Authors:  Andreas Reif; T Trang Nguyen; Lena Weissflog; Christian P Jacob; Marcel Romanos; Tobias J Renner; Henriette N Buttenschon; Sarah Kittel-Schneider; Alexandra Gessner; Heike Weber; Maria Neuner; Silke Gross-Lesch; Karin Zamzow; Susanne Kreiker; Susanne Walitza; Jobst Meyer; Christine M Freitag; Rosa Bosch; Miquel Casas; Nuria Gómez; Marta Ribasès; Mónica Bayès; Jan K Buitelaar; Lambertus A L M Kiemeney; J J Sandra Kooij; Cees C Kan; Martine Hoogman; Stefan Johansson; Kaya K Jacobsen; Per M Knappskog; Ole B Fasmer; Phil Asherson; Andreas Warnke; Hans-Jörgen Grabe; Jessie Mahler; Alexander Teumer; Henry Völzke; Ole N Mors; Helmut Schäfer; Josep Antoni Ramos-Quiroga; Bru Cormand; Jan Haavik; Barbara Franke; Klaus-Peter Lesch
Journal:  Neuropsychopharmacology       Date:  2011-07-13       Impact factor: 7.853

8.  Cadherin 13: human cis-regulation and selectively-altered addiction phenotypes and cerebral cortical dopamine in knockout mice.

Authors:  Jana Drgonova; Donna Walther; G Luke Hartstein; Mohammad O Bukhari; Michael H Baumann; Jonathan Katz; Frank Scott Hall; Elizabeth R Arnold; Shaun Flax; Anthony Riley; Olga Rivero-Martin; Klaus-Peter Lesch; Juan Troncoso; Barbara Ranscht; George R Uhl
Journal:  Mol Med       Date:  2016-08-18       Impact factor: 6.354

9.  Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior.

Authors:  Palle Duun Rohde; Lisbeth Strøm Madsen; Sandra Marie Neumann Arvidson; Volker Loeschcke; Ditte Demontis; Torsten Nygaard Kristensen
Journal:  Fly (Austin)       Date:  2016-03-08       Impact factor: 2.160

Review 10.  Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment.

Authors:  Christian Jacob
Journal:  J Neural Transm (Vienna)       Date:  2012-08-19       Impact factor: 3.575
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