Literature DB >> 18839056

Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test.

Małgorzata Dybała1, Agata Siwek, Ewa Poleszak, Andrzej Pilc, Gabriel Nowak.   

Abstract

The NMDA receptor antagonist, CGP 37849-induced reduction in immobility time in the forced swim test in mice was not antagonized by pre-treatment with the AMPA receptor antagonist NBQX. This is the first demonstration of the antidepressant effect of the NMDA antagonist not being dependent on the AMPA transmission.

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Year:  2008        PMID： 18839056     DOI： 10.1007/s00702-008-0128-2

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  11 in total

Review 1.  Current perspectives on the development of non-biogenic amine-based antidepressants.

Authors:  P Skolnick; B Legutko; X Li; F P Bymaster
Journal:  Pharmacol Res       Date:  2001-05       Impact factor: 7.658

Review 2.  AMPA receptors in the therapeutic management of depression.

Authors:  D Bleakman; A Alt; J M Witkin
Journal:  CNS Neurol Disord Drug Targets       Date:  2007-04       Impact factor: 4.388

3.  AMPA receptors: a target for novel antidepressants?

Authors:  Phil Skolnick
Journal:  Biol Psychiatry       Date:  2008-02-15       Impact factor: 13.382

4.  Lack of persistent effects of ketamine in rodent models of depression.

Authors:  Piotr Popik; Tomasz Kos; Magdalena Sowa-Kućma; Gabriel Nowak
Journal:  Psychopharmacology (Berl)       Date:  2008-05-07       Impact factor: 4.530

Review 5.  New approaches to antidepressant drug discovery: beyond monoamines.

Authors:  Olivier Berton; Eric J Nestler
Journal:  Nat Rev Neurosci       Date:  2006-02       Impact factor: 34.870

6.  Behavioral despair in mice: a primary screening test for antidepressants.

Authors:  R D Porsolt; A Bertin; M Jalfre
Journal:  Arch Int Pharmacodyn Ther       Date:  1977-10

Review 7.  Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.

Authors:  P Skolnick; R T Layer; P Popik; G Nowak; I A Paul; R Trullas
Journal:  Pharmacopsychiatry       Date:  1996-01       Impact factor: 5.788

8.  Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.

Authors:  Sungho Maeng; Carlos A Zarate; Jing Du; Robert J Schloesser; Joseph McCammon; Guang Chen; Husseini K Manji
Journal:  Biol Psychiatry       Date:  2007-07-23       Impact factor: 13.382

9.  Activation of the NMDA/glutamate receptor complex antagonizes the NMDA antagonist-induced antidepressant-like effects in the forced swim test.

Authors:  Ewa Poleszak; Piotr Wlaź; Andrzej Wróbel; Małgorzata Dybała; Magdalena Sowa; Sylwia Fidecka; Andrzej Pilc; Gabriel Nowak
Journal:  Pharmacol Rep       Date:  2007 Sep-Oct       Impact factor: 3.024

10.  CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity.

Authors:  G E Fagg; H R Olpe; M F Pozza; J Baud; M Steinmann; M Schmutz; C Portet; P Baumann; K Thedinga; H Bittiger
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739
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  4 in total

1.  Instant and Lasting Down-Regulation of NR1 Expression in the Hippocampus is Associated Temporally with Antidepressant Activity After Acute Yueju.

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Journal:  Cell Mol Neurobiol       Date:  2016-01-29       Impact factor: 5.046

Review 2.  Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders.

Authors:  Gerard Sanacora; Giulia Treccani; Maurizio Popoli
Journal:  Neuropharmacology       Date:  2011-08-03       Impact factor: 5.250

3.  Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice.

Authors:  Ewa Poleszak; Weronika Stasiuk; Aleksandra Szopa; Elżbieta Wyska; Anna Serefko; Anna Oniszczuk; Sylwia Wośko; Katarzyna Świąder; Piotr Wlaź
Journal:  Metab Brain Dis       Date:  2016-02-29       Impact factor: 3.584

Review 4.  A systematic review of studies investigating the acute effects of N-methyl-D-aspartate receptor antagonists on behavioural despair in normal animals suggests poor predictive validity.

Authors:  Martin Viktorov; Matthew P Wilkinson; Victoria C E Elston; Medi Stone; Emma S J Robinson
Journal:  Brain Neurosci Adv       Date:  2022-03-12
  4 in total

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