OBJECTIVES: Anaplastic thyroid carcinoma is associated with a high rate of local recurrence and poor prognosis. This analysis examines the effects of surgery and radiotherapy on survival. METHODS AND MATERIALS: Anaplastic thyroid carcinoma patients from the Surveillance, Epidemiology, and End Results database from 1983 to 2002 with > or = 1-month survival after diagnosis who either had surgery performed or recommended were included in the analysis. RESULTS: Two hundred sixty-one patients met the inclusion criteria for analysis. Median survival was 4 months. Distant or metastatic disease, tumor size >7 cm, and treatment with surgery plus or minus radiotherapy were statistically significant as prognostic for survival on multivariate analysis (P < 0.05). When stratified by extent of disease, the addition of radiotherapy to surgery resulted in improved survival for patients with disease extending into adjacent tissue (P = 0.05); however, patients who had disease confined to the capsule or had further extension or distant metastatic disease did not benefit from radiotherapy after surgery (P > 0.05). CONCLUSIONS: Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma. Aggressive treatment with surgery and chemoradiation should be encouraged.
OBJECTIVES:Anaplastic thyroid carcinoma is associated with a high rate of local recurrence and poor prognosis. This analysis examines the effects of surgery and radiotherapy on survival. METHODS AND MATERIALS: Anaplastic thyroid carcinomapatients from the Surveillance, Epidemiology, and End Results database from 1983 to 2002 with > or = 1-month survival after diagnosis who either had surgery performed or recommended were included in the analysis. RESULTS: Two hundred sixty-one patients met the inclusion criteria for analysis. Median survival was 4 months. Distant or metastatic disease, tumor size >7 cm, and treatment with surgery plus or minus radiotherapy were statistically significant as prognostic for survival on multivariate analysis (P < 0.05). When stratified by extent of disease, the addition of radiotherapy to surgery resulted in improved survival for patients with disease extending into adjacent tissue (P = 0.05); however, patients who had disease confined to the capsule or had further extension or distant metastatic disease did not benefit from radiotherapy after surgery (P > 0.05). CONCLUSIONS: Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma. Aggressive treatment with surgery and chemoradiation should be encouraged.
Authors: Kun-Tai Hsu; Xiao-Min Yu; Anjon W Audhya; Juan C Jaume; Ricardo V Lloyd; Shigeki Miyamoto; Tomas A Prolla; Herbert Chen Journal: Oncologist Date: 2014-09-26
Authors: Todd A Pezzi; Abdallah S R Mohamed; Tommy Sheu; Pierre Blanchard; Vlad C Sandulache; Stephen Y Lai; Maria E Cabanillas; Michelle D Williams; Christopher M Pezzi; Charles Lu; Adam S Garden; William H Morrison; David I Rosenthal; Clifton D Fuller; G Brandon Gunn Journal: Cancer Date: 2016-12-27 Impact factor: 6.860
Authors: Sibo Tian; Jeffrey M Switchenko; Teng Fei; Robert H Press; Mustafa Abugideiri; Nabil F Saba; Taofeek K Owonikoko; Amy Y Chen; Jonathan J Beitler; Walter J Curran; Theresa W Gillespie; Kristin A Higgins Journal: Head Neck Date: 2019-12-16 Impact factor: 3.147