OBJECTIVE: We examined the cross-sectional relationship between dietary vitamin B6 and plasma pyridoxyl-5'-phosphate concentrations (PLP) with depressive symptomatology among a representative sample of 618 elderly Caribbean Hispanics, and a neighborhood based comparison group of 251 non-Hispanic white (NHW) older adults in Massachusetts. METHODS: Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). 41% of Hispanics and 22.6% of NHWs had CES-D scores greater than 16, indicating depressive caseness. Dietary intake was calculated from a semi-quantitative food frequency questionnaire (FFQ) designed for this population. RESULTS: PLP was significantly associated with CES-D score and depressive caseness in the total sample and in non-supplement users. Deficient levels of plasma PLP (plasma PLP < 20 nmol/L) approximately doubled the likelihood of depressive caseness. Total intake (diet + supplement) of vitamin B(6) was not associated with these outcomes. However, dietary vitamin B(6) was significantly associated with CES-D score and depressive caseness. CONCLUSION: Longitudinal studies are needed to clarify the direction of causality between vitamin B6 and depressive symptoms.
OBJECTIVE: We examined the cross-sectional relationship between dietary vitamin B6 and plasma pyridoxyl-5'-phosphate concentrations (PLP) with depressive symptomatology among a representative sample of 618 elderly Caribbean Hispanics, and a neighborhood based comparison group of 251 non-Hispanic white (NHW) older adults in Massachusetts. METHODS:Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). 41% of Hispanics and 22.6% of NHWs had CES-D scores greater than 16, indicating depressive caseness. Dietary intake was calculated from a semi-quantitative food frequency questionnaire (FFQ) designed for this population. RESULTS: PLP was significantly associated with CES-D score and depressive caseness in the total sample and in non-supplement users. Deficient levels of plasma PLP (plasma PLP < 20 nmol/L) approximately doubled the likelihood of depressive caseness. Total intake (diet + supplement) of vitamin B(6) was not associated with these outcomes. However, dietary vitamin B(6) was significantly associated with CES-D score and depressive caseness. CONCLUSION: Longitudinal studies are needed to clarify the direction of causality between vitamin B6 and depressive symptoms.
Authors: Paul L Strickland; J F William Deakin; Carol Percival; Joanne Dixon; Richard A Gater; David P Goldberg Journal: Br J Psychiatry Date: 2002-02 Impact factor: 9.319
Authors: Christelle H Blunden; Hazel M Inskip; Sian M Robinson; Cyrus Cooper; Keith M Godfrey; Tony R Kendrick Journal: Ment Health Fam Med Date: 2012-01
Authors: Xingwang Ye; Chao-Qiang Lai; Jimmy W Crott; Aron M Troen; Jose M Ordovas; Katherine L Tucker Journal: Psychosom Med Date: 2011-05-19 Impact factor: 4.312