Literature DB >> 1883846

Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice.

H Shimano1, N Yamada, M Shimada, N Ohsawa, C Fukazawa, Y Yazaki, F Takaku, M Katsuki.   

Abstract

We created three lines of transgenic mice with an integrated rat genomic apolipoprotein E gene fused with the mouse metallothionein I promoter. These lines transcribed rat apoE mRNA in the liver and/or in the kidney and expressed significant amounts of rat apoE in plasma. Enhancement of the plasma level by treatment with Zn ion or Bi ion was observed.

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Year:  1991        PMID： 1883846     DOI： 10.1016/0167-4781(91)90041-j

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

Authors:  H Shimano; N Yamada; M Katsuki; K Yamamoto; T Gotoda; K Harada; M Shimada; Y Yazaki
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

2.  Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.

Authors:  H Shimano; Y Namba; J Ohsuga; M Kawamura; K Yamamoto; M Shimada; T Gotoda; K Harada; Y Yazaki; N Yamada
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

3.  Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

Authors:  S Bellosta; R W Mahley; D A Sanan; J Murata; D L Newland; J M Taylor; R E Pitas
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808

4.  Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

Authors:  H Shimano; N Yamada; M Katsuki; M Shimada; T Gotoda; K Harada; T Murase; C Fukazawa; F Takaku; Y Yazaki
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

5.  Testis-specific expression of a metallothionein I-driven transgene correlates with undermethylation of the locus in testicular DNA.

Authors:  K Salehi-Ashtiani; R J Widrow; C L Markert; E Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-01       Impact factor: 11.205

6.  Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

Authors:  H Shimano; J Ohsuga; M Shimada; Y Namba; T Gotoda; K Harada; M Katsuki; Y Yazaki; N Yamada
Journal:  J Clin Invest       Date:  1995-02       Impact factor: 14.808
  6 in total

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