Literature DB >> 18838174

Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain.

Ethika Tyagi1, Rahul Agrawal, Chandishwar Nath, Rakesh Shukla.   

Abstract

In the present study, neuroinflammation was induced by bilateral intracerebroventricular (ICV) administration of Lipopolysaccharide (LPS). Proinflammatory cytokines (TNF-alpha and IL-1beta), acetylcholinesterase (AChE) activity, malondialdehyde (MDA) and reduced glutathione (GSH) were studied as markers for neuroinflammation, cholinergic activity and oxidative stress respectively in different brain regions at different time points after LPS injection. LPS produced increase in proinflammatory cytokines, MDA and the decrease in level of GSH at 24 h indicating a state of inflammation in brain regions, which was significantly blocked by Ibuprofen, a non steroidal anti-inflammatory drug. Enhanced AChE activity with these inflammatory markers after LPS administration indicates a possible relationship between neuroinflammation and cholinergic system during the development of neurodegenerative diseases.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18838174     DOI： 10.1016/j.jneuroim.2008.08.015

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  25 in total

1.  Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation.

Authors:  Chris J Reisenauer; Dhaval P Bhatt; Dane J Mitteness; Evan R Slanczka; Heidi M Gienger; John A Watt; Thad A Rosenberger
Journal:  J Neurochem       Date:  2011-02-24       Impact factor: 5.372

2.  The effects of exercise on hippocampal inflammatory cytokine levels, brain oxidative stress markers and memory impairments induced by lipopolysaccharide in rats.

Authors:  Zahra Jahangiri; Zahra Gholamnezhad; Mahmoud Hosseini
Journal:  Metab Brain Dis       Date:  2019-04-01       Impact factor: 3.584

3.  Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats.

Authors:  N Rajasekar; Chandishwar Nath; Kashif Hanif; Rakesh Shukla
Journal:  Mol Neurobiol       Date:  2016-10-11       Impact factor: 5.590

4.  Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice.

Authors:  Chetan Thingore; Viplav Kshirsagar; Archana Juvekar
Journal:  Metab Brain Dis       Date:  2020-10-17       Impact factor: 3.584

5.  Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.

Authors:  Aya Shoukry Sayed; Nesrine Salah El Dine El Sayed
Journal:  J Mol Neurosci       Date:  2016-03-16       Impact factor: 3.444

6.  Ameliorative Effect of Ginsenoside Rg1 on Lipopolysaccharide-Induced Cognitive Impairment: Role of Cholinergic System.

Authors:  Yang Jin; Jian Peng; Xiaona Wang; Dong Zhang; Tianyin Wang
Journal:  Neurochem Res       Date:  2017-01-11       Impact factor: 3.996

7.  Possible Mechanisms Involved in Attenuation of Lipopolysaccharide-Induced Memory Deficits by Methyl Jasmonate in Mice.

Authors:  Anthony Taghogho Eduviere; Solomon Umukoro; Olusegun A Adeoluwa; Itivere Adrian Omogbiya; Oritoke Modupe Aluko
Journal:  Neurochem Res       Date:  2016-09-02       Impact factor: 3.996

8.  Lipopolysaccharide-induced radical formation in the striatum is abolished in Nox2 gp91phox-deficient mice.

Authors:  Hans-Willi Clement; Juan F Vazquez; Olaf Sommer; Philip Heiser; Henning Morawietz; Ulrich Hopt; Eberhard Schulz; Ernst von Dobschütz
Journal:  J Neural Transm (Vienna)       Date:  2009-10-29       Impact factor: 3.575

9.  7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence.

Authors:  Surya Narayan Pandey; Mohit Kwatra; Durgesh Kumar Dwivedi; Priyansha Choubey; Mangala Lahkar; Ashok Jangra
Journal:  Psychopharmacology (Berl)       Date:  2020-03-23       Impact factor: 4.530

10.  Hydrogen Sulfide Ameliorates Lipopolysaccharide-Induced Memory Impairment in Mice by Reducing Apoptosis, Oxidative, and Inflammatory Effects.

Authors:  Viplav Kshirsagar; Chetan Thingore; Malvika Gursahani; Nitin Gawali; Archana Juvekar
Journal:  Neurotox Res       Date:  2021-05-22       Impact factor: 3.911
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.