| Literature DB >> 18837553 |
Tomoya Miura1, Takeharu Toyoshima, Yusuke Takahashi, Masahiro Murakami.
Abstract
A palladium(0)/monophosphine catalyst promotes a cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents to produce stereodefined 3-alkylideneoxindoles. The alkynyl and isocyanato groups undergo oxidative cyclization with Pd(0) to form an oxapalladacycle intermediate. Subsequent transmetalation and reductive elimination afford the product.Entities:
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Year: 2008 PMID： 18837553 DOI： 10.1021/ol801844w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005