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Literature DB >> 18836305

The role of MXI1 in VHL deficient tumorigenesis.

Waihay J Wong¹, M Celeste Simon.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18836305 PMCID： PMC3141207 DOI： 10.4161/cbt.7.10.6917

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742

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17 in total

1. Sunitinib in patients with metastatic renal cell carcinoma.

Authors: Robert J Motzer; Brian I Rini; Ronald M Bukowski; Brendan D Curti; Daniel J George; Gary R Hudes; Bruce G Redman; Kim A Margolin; Jaime R Merchan; George Wilding; Michelle S Ginsberg; Jennifer Bacik; Sindy T Kim; Charles M Baum; M Dror Michaelson
Journal: JAMA Date: 2006-06-07 Impact factor: 56.272

2. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Authors: Raju R Raval; Kah Weng Lau; Maxine G B Tran; Heidi M Sowter; Stefano J Mandriota; Ji-Liang Li; Christopher W Pugh; Patrick H Maxwell; Adrian L Harris; Peter J Ratcliffe
Journal: Mol Cell Biol Date: 2005-07 Impact factor: 4.272

3. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

Authors: Minori Koshiji; Kenneth K-W To; Stefanie Hammer; Kensuke Kumamoto; Adrian L Harris; Paul Modrich; L Eric Huang
Journal: Mol Cell Date: 2005-03-18 Impact factor: 17.970

4. The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.

Authors: M A Kuczyk; J Serth; C Bokemeyer; J Schwede; R Herrmann; S Machtens; V Grünewald; K Höfner; U Jonas
Journal: Oncol Rep Date: 1998 Jan-Feb Impact factor: 3.906

5. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

Authors: Paul G Corn; M Stacey Ricci; Kimberly A Scata; Andrew M Arsham; M Celeste Simon; David T Dicker; Wafik S El-Deiry
Journal: Cancer Biol Ther Date: 2005-11-07 Impact factor: 4.742

6. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.

Authors: N Schreiber-Agus; Y Meng; T Hoang; H Hou; K Chen; R Greenberg; C Cordon-Cardo; H W Lee; R A DePinho
Journal: Nature Date: 1998-06-04 Impact factor: 49.962

7. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

Authors: Minori Koshiji; Yukio Kageyama; Erin A Pete; Izumi Horikawa; J Carl Barrett; L Eric Huang
Journal: EMBO J Date: 2004-04-08 Impact factor: 11.598

8. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.

Authors: Huafeng Zhang; Ping Gao; Ryo Fukuda; Ganesh Kumar; Balaji Krishnamachary; Karen I Zeller; Chi V Dang; Gregg L Semenza
Journal: Cancer Cell Date: 2007-05 Impact factor: 31.743

The role of MXI1 in VHL deficient tumorigenesis.

1. Sunitinib in patients with metastatic renal cell carcinoma.

2. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

3. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

4. The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.

5. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

6. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.

7. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

8. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.

9. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis.

10. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

1. N-Myc differentially regulates expression of MXI1 isoforms in neuroblastoma.

2. Mxi1 and mxi1-0 antagonize N-myc function and independently mediate apoptosis in neuroblastoma.