| Literature DB >> 18835720 |
Adriana S Brito1, Dayse S Arimatéia, Lucilla R Souza, Marcelo A Lima, Vanessa O Santos, Valquíria P Medeiros, Paula A Ferreira, Rodrigo A Silva, Carmen V Ferreira, Giselle Z Justo, Edda L Leite, Giulianna P V Andrade, Fernanda W Oliveira, Helena B Nader, Suely F Chavante.
Abstract
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p<0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.Entities:
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Year: 2008 PMID： 18835720 DOI： 10.1016/j.bmc.2008.09.020
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641