Literature DB >> 18835269

Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?

F Kaya1, S Belin, Gr Diamantidis, M Fontes.   

Abstract

Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid (AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues.

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Year:  2008        PMID： 18835269     DOI： 10.1016/j.febslet.2008.09.040

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1.

Authors:  Andrea K Kress; Grit Schneider; Klemens Pichler; Martina Kalmer; Bernhard Fleckenstein; Ralph Grassmann
Journal:  J Virol       Date:  2010-06-23       Impact factor: 5.103

Review 2.  The PMP22 gene and its related diseases.

Authors:  Jun Li; Brett Parker; Colin Martyn; Chandramohan Natarajan; Jiasong Guo
Journal:  Mol Neurobiol       Date:  2012-12-07       Impact factor: 5.590

3.  Intracellular Ascorbate Prevents Endothelial Barrier Permeabilization by Thrombin.

Authors:  William H Parker; Zhi-chao Qu; James M May
Journal:  J Biol Chem       Date:  2015-07-07       Impact factor: 5.157

4.  Ascorbic Acid and gene expression: another example of regulation of gene expression by small molecules?

Authors:  Sophie Belin; Ferdinand Kaya; Stéphane Burtey; Michel Fontes
Journal:  Curr Genomics       Date:  2010-03       Impact factor: 2.236

5.  Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A.

Authors:  Min Han; Suresh Pendem; Suet Ling Teh; Dinesh K Sukumaran; Feng Wu; John X Wilson
Journal:  Free Radic Biol Med       Date:  2009-10-17       Impact factor: 7.376

6.  Haplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.

Authors:  Megan Hwa Brewer; Ki Hwan Ma; Gary W Beecham; Chetna Gopinath; Frank Baas; Byung-Ok Choi; Mary M Reilly; Michael E Shy; Stephan Züchner; John Svaren; Anthony Antonellis
Journal:  Hum Mol Genet       Date:  2014-05-15       Impact factor: 6.150

Review 7.  A brief review of recent Charcot-Marie-Tooth research and priorities.

Authors:  Sean Ekins; Nadia K Litterman; Renée J G Arnold; Robert W Burgess; Joel S Freundlich; Steven J Gray; Joseph J Higgins; Brett Langley; Dianna E Willis; Lucia Notterpek; David Pleasure; Michael W Sereda; Allison Moore
Journal:  F1000Res       Date:  2015-02-26

8.  Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool.

Authors:  Fryad Rahman; Fadi Al Frouh; Benoit Bordignon; Marc Fraterno; Jean-François Landrier; Franck Peiretti; Michel Fontes
Journal:  Front Cell Dev Biol       Date:  2014-08-07

Review 9.  Therapeutic Development in Charcot Marie Tooth Type 1 Disease.

Authors:  Pierre Miniou; Michel Fontes
Journal:  Int J Mol Sci       Date:  2021-06-23       Impact factor: 5.923

10.  Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression.

Authors:  Sophie Belin; Ferdinand Kaya; Ghislaine Duisit; Sarah Giacometti; Joseph Ciccolini; Michel Fontés
Journal:  PLoS One       Date:  2009-02-06       Impact factor: 3.240
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