Literature DB >> 18835180

3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication.

Daniela Iannazzo1, Anna Piperno, Giovanni Romeo, Roberto Romeo, Ugo Chiacchio, Antonio Rescifina, Emanuela Balestrieri, Beatrice Macchi, Antonio Mastino, Riccardo Cortese.   

Abstract

A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.

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Year:  2008        PMID: 18835180     DOI: 10.1016/j.bmc.2008.09.006

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  1 in total

1.  3-{2-[(1,3-Benzothia-zol-2-yl)sulfanyl-meth-yl]phen-yl}-4-meth-oxy-5,5-dimethyl-furan-2(5H)-one.

Authors:  Anna Duan; Haikui Yang; Peiliang Zhao; Wenwei You
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-23
  1 in total

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