| Literature DB >> 18835164 |
Antonio Garrido Montalban1, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G J Delaet, Eric Erb, Andrew Gibbs, Jeff Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Ed Roberts, Eddine Saiah, Robert Sullivan, Zhijun Wang, Christopher J Larson.
Abstract
We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addition results in improve potencies against p38.Entities:
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Year: 2008 PMID： 18835164 DOI： 10.1016/j.bmcl.2008.09.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823