Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Literature DB >> 18835029

Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Abstract

Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18835029 DOI： 10.1016/j.ccr.2008.09.007

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

Keyword Cloud
Cited

31 in total

1. Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway.

Authors: Libin Song; Xiangyuan Chen; Song Gao; Chenyue Zhang; Chao Qu; Peng Wang; Luming Liu
Journal: Tumour Biol Date: 2016-10-12

2. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.

Authors: Samer Singh; Zhiqiang Wang; Dennis Liang Fei; Kendall E Black; John A Goetz; Robert Tokhunts; Camilla Giambelli; Jezabel Rodriguez-Blanco; Jun Long; Ethan Lee; Karoline J Briegel; Pablo A Bejarano; Ethan Dmitrovsky; Anthony J Capobianco; David J Robbins
Journal: Cancer Res Date: 2011-05-12 Impact factor: 12.701

3. Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling.

Authors: Sunday A Abiria; Thomas V Williams; Alexander L Munden; Vandana K Grover; Ato Wallace; Christopher J Lundberg; J Gerardo Valadez; Michael K Cooper
Journal: J Neurooncol Date: 2014-05-28 Impact factor: 4.130

4. Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.

Authors: Adam Steg; Hope M Amm; Zdenek Novak; Andra R Frost; Martin R Johnson
Journal: Cancer Biol Ther Date: 2010-11-01 Impact factor: 4.742

5. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.

Authors: Yan Chen; Shen Yue; Lu Xie; Xiao-hong Pu; Tian Jin; Steven Y Cheng
Journal: J Biol Chem Date: 2011-02-11 Impact factor: 5.157

Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

1. Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway.

2. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.

3. Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling.

4. Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.

5. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.

6. Smoothened antagonists reverse taxane resistance in ovarian cancer.

Review 7. Hedgehog signalling in breast cancer.

Review 8. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals.

9. Sonic Hedgehog pathway activity in prostate cancer.

10. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft.