PURPOSE: To determine the efficacy of low-dose palliative radiotherapy for both low-grade malignant cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (mycosis fungoides). METHODS AND MATERIALS: A total of 18 patients with low-grade CBCL (10 primary cutaneous marginal zone B-cell and 8 primary cutaneous follicle center lymphomas) with 44 symptomatic plaques and tumors underwent low-dose (4 Gy in two fractions) local radiotherapy. A total of 31 patients with mycosis fungoides were treated at 82 symptomatic sites, initially with 4 Gy and later with 8 Gy in two fractions. RESULTS: The complete response rate for CBCL lesions was 72%. Of the 44 B-cell lymphoma lesions, 13 were re-treated to the same site after a median of 6.3 months because of persistent (n = 8) or recurrent (n = 5) symptomatic disease. Of the mycosis fungoides patients treated with 4 Gy in two fractions (17 lesions), 70% failed to respond. Increasing the dose to 8 Gy in two fractions yielded a complete response rate of 92% (60 of 65 lesions). The patients in whom low-dose radiotherapy failed were retreated with 20 Gy in eight fractions. CONCLUSION: Our results have demonstrated that low-dose involved-field radiotherapy induces a high response rate in both CBCL and cutaneous T-cell lymphoma lesions without any toxicity. Therefore, this treatment is now our standard palliative treatment. At progression, it is safe and feasible to apply greater radiation doses.
PURPOSE: To determine the efficacy of low-dose palliative radiotherapy for both low-grade malignant cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (mycosis fungoides). METHODS AND MATERIALS: A total of 18 patients with low-grade CBCL (10 primary cutaneous marginal zone B-cell and 8 primary cutaneous follicle center lymphomas) with 44 symptomatic plaques and tumors underwent low-dose (4 Gy in two fractions) local radiotherapy. A total of 31 patients with mycosis fungoides were treated at 82 symptomatic sites, initially with 4 Gy and later with 8 Gy in two fractions. RESULTS: The complete response rate for CBCL lesions was 72%. Of the 44 B-cell lymphoma lesions, 13 were re-treated to the same site after a median of 6.3 months because of persistent (n = 8) or recurrent (n = 5) symptomatic disease. Of the mycosis fungoidespatients treated with 4 Gy in two fractions (17 lesions), 70% failed to respond. Increasing the dose to 8 Gy in two fractions yielded a complete response rate of 92% (60 of 65 lesions). The patients in whom low-dose radiotherapy failed were retreated with 20 Gy in eight fractions. CONCLUSION: Our results have demonstrated that low-dose involved-field radiotherapy induces a high response rate in both CBCL and cutaneous T-cell lymphoma lesions without any toxicity. Therefore, this treatment is now our standard palliative treatment. At progression, it is safe and feasible to apply greater radiation doses.
Authors: John T O'Malley; Adele de Masson; Elizabeth L Lowry; Anita Giobbie-Hurder; Nicole R LeBoeuf; Cecilia Larocca; Ahmed Gehad; Edward Seger; Jessica E Teague; David C Fisher; Thomas S Kupper; Phillip M Devlin; Rachael A Clark Journal: Clin Cancer Res Date: 2019-10-21 Impact factor: 12.531
Authors: Khaled Elsayad; Gabriele Reinartz; Michael Oertel; Stephan Rehn; Jens Eismann; Sergiu Scobioala; Hendrik Berssenbrügge; Nicole Eter; Carsten Weishaupt; Hartmut H Schmidt; Birte Friedrichs; Inga Grünewald; Wolfgang Hartmann; Georg Lenz; Eva Wardelmann; Normann Willich; Hans Theodor Eich Journal: Strahlenther Onkol Date: 2019-11-15 Impact factor: 3.621
Authors: Fabio Ynoe de Moraes; Heloisa de Andrade Carvalho; Samir Abdallah Hanna; João Luis Fernandes da Silva; Gustavo Nader Marta Journal: Rep Pract Oncol Radiother Date: 2013-09-27
Authors: Amrita Goyal; Joi B Carter; Itai Pashtan; Sara Gallotto; Irene Wang; Scott Isom; Andrea Ng; Karen M Winkfield Journal: J Am Acad Dermatol Date: 2018-02 Impact factor: 11.527