Literature DB >> 1883392

GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent.

T Fridolf1, B Ahrén.   

Abstract

We examined the Na(+)-dependency of the effects of GLP-1(7-36)amide in normal, overnight cultured rat islets. It was found that GLP-1(7-36)amide stimulated insulin secretion, 45Ca(2+)-efflux, and 86Rb(+)-efflux from prelabelled islets. All these effects were abolished by omitting Na+ from the medium and replacing it with N-methyl-glucamine. This suggests that GLP-1(7-36)amide stimulates insulin secretion by depolarizing the beta-cells by increasing their permeability to Na+.

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Year:  1991        PMID： 1883392     DOI： 10.1016/0006-291x(91)91429-g

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

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  3 in total

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