Literature DB >> 1883351

O-hydroxyphenylacetaldehyde: a major novel metabolite of coumarin formed by rat, gerbil and human liver microsomes.

J H Fentem1, J R Fry, D A Whiting.   

Abstract

A major novel coumarin metabolite was isolated from rat hepatic microsomal incubations by high-performance liquid chromatography. In the presence of a rat liver cytosolic fraction and NADH it was rapidly metabolized to O-hydroxyphenylethanol. The metabolite co-chromatographed with an authentic sample of O-hydroxyphenylacetaldehyde and its identity was confirmed by mass spectral analysis. The formation of O-hydroxyphenylacetaldehyde from coumarin was NADPH-dependent. It was the major metabolite formed by rat, gerbil and human liver microsomes at a coumarin concentration of 1mM.

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Year:  1991        PMID： 1883351     DOI： 10.1016/0006-291x(91)91354-f

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

1.  A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products.

Authors:  Maria T Baltazar; Sophie Cable; Paul L Carmichael; Richard Cubberley; Tom Cull; Mona Delagrange; Matthew P Dent; Sarah Hatherell; Jade Houghton; Predrag Kukic; Hequn Li; Mi-Young Lee; Sophie Malcomber; Alistair M Middleton; Thomas E Moxon; Alexis V Nathanail; Beate Nicol; Ruth Pendlington; Georgia Reynolds; Joe Reynolds; Andrew White; Carl Westmoreland
Journal:  Toxicol Sci       Date:  2020-07-01       Impact factor: 4.849

2.  New Metabolites of Coumarin Detected in Human Urine Using Ultra Performance Liquid Chromatography/Quadrupole-Time-of-Flight Tandem Mass Spectrometry.

Authors:  Letícia Paula Leonart; João Cleverson Gasparetto; Flávia Lada Degaut Pontes; Letícia Bonancio Cerqueira; Thais Martins Guimarães de Francisco; Roberto Pontarolo
Journal:  Molecules       Date:  2017-11-22       Impact factor: 4.411
  2 in total

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