OBJECTIVE AND METHOD: There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorder patients during acute mania and in healthy controls. RESULTS: Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorder patients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group.. CONCLUSION: These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.
OBJECTIVE AND METHOD: There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorderpatients during acute mania and in healthy controls. RESULTS: Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorderpatients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group.. CONCLUSION: These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.
Authors: Sarah J Blossom; Stepan Melnyk; Craig A Cooney; Kathleen M Gilbert; S Jill James Journal: Neurotoxicology Date: 2012-03-07 Impact factor: 4.294
Authors: Samira S Valvassori; Karen V Calixto; Josiane Budni; Wilson R Resende; Roger B Varela; Karolina V de Freitas; Cinara L Gonçalves; Emilio L Streck; João Quevedo Journal: J Neural Transm (Vienna) Date: 2013-07-14 Impact factor: 3.575
Authors: Gabriela K Ferreira; Giselli Scaini; Isabela C Jeremias; Milena Carvalho-Silva; Cinara L Gonçalves; Talita C B Pereira; Giovanna M T Oliveira; Luiza W Kist; Maurício R Bogo; Patrícia F Schuck; Gustavo C Ferreira; Emilio L Streck Journal: Mol Neurobiol Date: 2013-10-04 Impact factor: 5.590