Nicholas M Burton1, David J Anstee. 1. Department of Biochemistry, University of Bristol and Bristol Institute for Transfusion Sciences, National Blood Service, Bristol, UK.
Abstract
PURPOSE OF REVIEW: The present article reviews recent data concerning the structure and function of the Rh-associated glycoprotein (RhAG) and considers what can be inferred about the structure and functional significance of the D and CE polypeptides. RECENT FINDINGS: The structure of a bacterial RhAG (from Nitrosomonas europaea) has been solved and its gas channel elucidated. This information allows us to model a more accurate structure of RhD and RhCE polypeptides than has been possible hitherto. Human RhAG has been shown to act as a gas channel for CO2. SUMMARY: Elucidation of the structure of a bacterial RhAG allows us to model the structure of D and CE polypeptides more accurately than before. Results suggest that whereas RhAG has a channel for passage of neutral gases (CO2, NH3 and possibly oxygen and nitric oxide), D and CE polypeptides are unlikely to have a transport function.
PURPOSE OF REVIEW: The present article reviews recent data concerning the structure and function of the Rh-associated glycoprotein (RhAG) and considers what can be inferred about the structure and functional significance of the D and CE polypeptides. RECENT FINDINGS: The structure of a bacterial RhAG (from Nitrosomonas europaea) has been solved and its gas channel elucidated. This information allows us to model a more accurate structure of RhD and RhCE polypeptides than has been possible hitherto. HumanRhAG has been shown to act as a gas channel for CO2. SUMMARY: Elucidation of the structure of a bacterial RhAG allows us to model the structure of D and CE polypeptides more accurately than before. Results suggest that whereas RhAG has a channel for passage of neutral gases (CO2, NH3 and possibly oxygen and nitric oxide), D and CE polypeptides are unlikely to have a transport function.
Authors: Kris P Jeremy; Zoe E Plummer; David J Head; Tracey E Madgett; Kelly L Sanders; Amanda Wallington; Jill R Storry; Florinda Gilsanz; Jean Delaunay; Neil D Avent Journal: Haematologica Date: 2009-10 Impact factor: 9.941
Authors: Alice C N Brown; Dalila Hallouane; William J Mawby; Fiona E Karet; Moin A Saleem; Alexander J Howie; Ashley M Toye Journal: Am J Physiol Renal Physiol Date: 2009-04-08