Literature DB >> 18832884

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein.

Barbara Ensoli1, Valeria Fiorelli, Fabrizio Ensoli, Adriano Lazzarin, Raffaele Visintini, Pasquale Narciso, Aldo Di Carlo, Paolo Monini, Mauro Magnani, Enrico Garaci.   

Abstract

The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the adjuvant effects on dendritic cells. Safety, immunogenicity and efficacy data in monkeys support the development of this vaccine concept.

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Year:  2008        PMID： 18832884     DOI： 10.1097/QAD.0b013e32831392d4

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  19 in total

1.  Effect of the redox state on HIV-1 tat protein multimerization and cell internalization and trafficking.

Authors:  Raffaella Pierleoni; Michele Menotta; Antonella Antonelli; Carla Sfara; Giordano Serafini; Sabrina Dominici; Maria Elena Laguardia; Annalisa Salis; Gianluca Damonte; Lucia Banci; Marco Porcu; Paolo Monini; Barbara Ensoli; Mauro Magnani
Journal:  Mol Cell Biochem       Date:  2010-08-20       Impact factor: 3.396

2.  Effects of different routes of administration on the immunogenicity of the Tat protein and a Tat-derived peptide.

Authors:  Valentina Finessi; Francesco Nicoli; Eleonora Gallerani; Fabio Sforza; Mariaconcetta Sicurella; Aurelio Cafaro; Antonella Caputo; Barbara Ensoli; Riccardo Gavioli
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

3.  Identification of a highly conserved surface on Tat variants.

Authors:  Sonia Mediouni; Albert Darque; Isabelle Ravaux; Gilbert Baillat; Christian Devaux; Erwann P Loret
Journal:  J Biol Chem       Date:  2013-05-15       Impact factor: 5.157

4.  Impact of viral dose and major histocompatibility complex class IB haplotype on viral outcome in mauritian cynomolgus monkeys vaccinated with Tat upon challenge with simian/human immunodeficiency virus SHIV89.6P.

Authors:  Aurelio Cafaro; Stefania Bellino; Fausto Titti; Maria Teresa Maggiorella; Leonardo Sernicola; Roger W Wiseman; David Venzon; Julie A Karl; David O'Connor; Paolo Monini; Marjorie Robert-Guroff; Barbara Ensoli
Journal:  J Virol       Date:  2010-06-16       Impact factor: 5.103

5.  Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART.

Authors:  Barbara Ensoli; Stefania Bellino; Antonella Tripiciano; Olimpia Longo; Vittorio Francavilla; Simone Marcotullio; Aurelio Cafaro; Orietta Picconi; Giovanni Paniccia; Arianna Scoglio; Angela Arancio; Cristina Ariola; Maria J Ruiz Alvarez; Massimo Campagna; Donato Scaramuzzi; Cristina Iori; Roberto Esposito; Cristina Mussini; Florio Ghinelli; Laura Sighinolfi; Guido Palamara; Alessandra Latini; Gioacchino Angarano; Nicoletta Ladisa; Fabrizio Soscia; Vito S Mercurio; Adriano Lazzarin; Giuseppe Tambussi; Raffaele Visintini; Francesco Mazzotta; Massimo Di Pietro; Massimo Galli; Stefano Rusconi; Giampiero Carosi; Carlo Torti; Giovanni Di Perri; Stefano Bonora; Fabrizio Ensoli; Enrico Garaci
Journal:  PLoS One       Date:  2010-11-11       Impact factor: 3.240

6.  Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with multigenic vaccines.

Authors:  Ruth H Florese; Thorsten Demberg; Peng Xiao; LaRene Kuller; Kay Larsen; L Ebonita Summers; David Venzon; Aurelio Cafaro; Barbara Ensoli; Marjorie Robert-Guroff
Journal:  J Immunol       Date:  2009-03-15       Impact factor: 5.422

7.  HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial.

Authors:  Fabrizio Ensoli; Aurelio Cafaro; Anna Casabianca; Antonella Tripiciano; Stefania Bellino; Olimpia Longo; Vittorio Francavilla; Orietta Picconi; Cecilia Sgadari; Sonia Moretti; Maria R Pavone Cossut; Angela Arancio; Chiara Orlandi; Leonardo Sernicola; Maria T Maggiorella; Giovanni Paniccia; Cristina Mussini; Adriano Lazzarin; Laura Sighinolfi; Guido Palamara; Andrea Gori; Gioacchino Angarano; Massimo Di Pietro; Massimo Galli; Vito S Mercurio; Francesco Castelli; Giovanni Di Perri; Paolo Monini; Mauro Magnani; Enrico Garaci; Barbara Ensoli
Journal:  Retrovirology       Date:  2015-04-29       Impact factor: 4.602

8.  HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies.

Authors:  Paolo Monini; Aurelio Cafaro; Indresh K Srivastava; Sonia Moretti; Victoria A Sharma; Claudia Andreini; Chiara Chiozzini; Flavia Ferrantelli; Maria R Pavone Cossut; Antonella Tripiciano; Filomena Nappi; Olimpia Longo; Stefania Bellino; Orietta Picconi; Emanuele Fanales-Belasio; Alessandra Borsetti; Elena Toschi; Ilaria Schiavoni; Ilaria Bacigalupo; Elaine Kan; Leonardo Sernicola; Maria T Maggiorella; Katy Montin; Marco Porcu; Patrizia Leone; Pasqualina Leone; Barbara Collacchi; Clelia Palladino; Barbara Ridolfi; Mario Falchi; Iole Macchia; Jeffrey B Ulmer; Stefano Buttò; Cecilia Sgadari; Mauro Magnani; Maurizio P M Federico; Fausto Titti; Lucia Banci; Franco Dallocchio; Rino Rappuoli; Fabrizio Ensoli; Susan W Barnett; Enrico Garaci; Barbara Ensoli
Journal:  PLoS One       Date:  2012-11-13       Impact factor: 3.240

9.  Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.

Authors:  Larance Ronsard; Sneh Lata; Jyotsna Singh; Vishnampettai G Ramachandran; Shukla Das; Akhil C Banerjea
Journal:  PLoS One       Date:  2014-01-23       Impact factor: 3.240

10.  The presence of anti-Tat antibodies in HIV-infected individuals is associated with containment of CD4+ T-cell decay and viral load, and with delay of disease progression: results of a 3-year cohort study.

Authors:  Stefania Bellino; Antonella Tripiciano; Orietta Picconi; Vittorio Francavilla; Olimpia Longo; Cecilia Sgadari; Giovanni Paniccia; Angela Arancio; Gioacchino Angarano; Nicoletta Ladisa; Adriano Lazzarin; Giuseppe Tambussi; Silvia Nozza; Carlo Torti; Emanuele Focà; Guido Palamara; Alessandra Latini; Laura Sighinolfi; Francesco Mazzotta; Massimo Di Pietro; Giovanni Di Perri; Stefano Bonora; Vito S Mercurio; Cristina Mussini; Andrea Gori; Massimo Galli; Paolo Monini; Aurelio Cafaro; Fabrizio Ensoli; Barbara Ensoli
Journal:  Retrovirology       Date:  2014-06-24       Impact factor: 4.602
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