Literature DB >> 18832590

Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification.

Lixin Kan1, Yijie Liu, Tammy L McGuire, Diana M Palila Berger, Rajeshwar B Awatramani, Susan M Dymecki, John A Kessler.   

Abstract

Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.

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Year:  2009        PMID： 18832590      PMCID： PMC2752983          DOI： 10.1634/stemcells.2008-0576

Source DB:  PubMed          Journal:  Stem Cells        ISSN： 1066-5099            Impact factor:   6.277


  43 in total

1.  Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model.

Authors:  F Alves-Rosa; C Stanganelli; J Cabrera; N van Rooijen; M S Palermo; M A Isturiz
Journal:  Blood       Date:  2000-10-15       Impact factor: 22.113

2.  Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord.

Authors:  P G Popovich; W F Hickey
Journal:  J Neuropathol Exp Neurol       Date:  2001-07       Impact factor: 3.685

3.  Mesenchymal stem cells: revisiting history, concepts, and assays.

Authors:  Paolo Bianco; Pamela Gehron Robey; Paul J Simmons
Journal:  Cell Stem Cell       Date:  2008-04-10       Impact factor: 24.633

4.  Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

Authors:  B E Clausen; C Burkhardt; W Reith; R Renkawitz; I Förster
Journal:  Transgenic Res       Date:  1999-08       Impact factor: 2.788

5.  Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2.

Authors:  C M Champagne; J Takebe; S Offenbacher; L F Cooper
Journal:  Bone       Date:  2002-01       Impact factor: 4.398

6.  Mast cell involvement in fibrodysplasia ossificans progressiva.

Authors:  F H Gannon; D Glaser; R Caron; L D Thompson; E M Shore; F S Kaplan
Journal:  Hum Pathol       Date:  2001-08       Impact factor: 3.466

7.  Effects of single-dose versus fractionated irradiation on the suppression of heterotopic bone formation--an animal model-based follow-up study in rats.

Authors:  S A Esenwein; S Sell; G Herr; C Gaissmaier; M Bamberg; G Möllenhoff; W Küsswetter; G Muhr
Journal:  Arch Orthop Trauma Surg       Date:  2000       Impact factor: 3.067

8.  Venous stasis causes release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) by monocyte-macrophage.

Authors:  S S Signorelli; M G Malaponte; L Di Pino; M P Costa; G Pennisi; M C Mazzarino
Journal:  Clin Hemorheol Microcirc       Date:  2000       Impact factor: 2.375

9.  Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates striatal macrophage invasion and neurodegeneration following local endotoxin infusion in gerbils.

Authors:  M A Zito; L A Koennecke; M J McAuliffe; B McNally; N van Rooijen; M P Heyes
Journal:  Brain Res       Date:  2001-02-16       Impact factor: 3.252

10.  Early myotome specification regulates PDGFA expression and axial skeleton development.

Authors:  M D Tallquist; K E Weismann; M Hellström; P Soriano
Journal:  Development       Date:  2000-12       Impact factor: 6.868
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  75 in total

1.  FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis.

Authors:  Qi-Quan Huang; Harris Perlman; Zan Huang; Robert Birkett; Lixin Kan; Hemant Agrawal; Alexander Misharin; Sandeep Gurbuxani; John D Crispino; Richard M Pope
Journal:  Blood       Date:  2010-08-19       Impact factor: 22.113

2.  Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification.

Authors:  Michael N Wosczyna; Arpita A Biswas; Catherine A Cogswell; David J Goldhamer
Journal:  J Bone Miner Res       Date:  2012-05       Impact factor: 6.741

3.  Picking a bone with heterotopic ossification: translational progress current and future.

Authors:  Jonathan R Peterson; Shailesh Agarwal; Shawn J Loder; Oluwatobi Eboda; Paul S Cederna; Steven R Buchman; Chuanwu Xi; Stewart C Wang; Benjamin Levi
Journal:  Ann Transl Med       Date:  2015-08

4.  Osteogenic potential of alpha smooth muscle actin expressing muscle resident progenitor cells.

Authors:  Brya G Matthews; Elena Torreggiani; Emilie Roeder; Igor Matic; Danka Grcevic; Ivo Kalajzic
Journal:  Bone       Date:  2015-12-22       Impact factor: 4.398

5.  Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor, that causes fibrodysplasia ossificans progressiva.

Authors:  Frederick S Kaplan; Petra Seemann; Julia Haupt; Meiqi Xu; Vitali Y Lounev; Mary Mullins; Eileen M Shore
Journal:  Methods Enzymol       Date:  2010       Impact factor: 1.600

Review 6.  Stem cells and heterotopic ossification: Lessons from animal models.

Authors:  John B Lees-Shepard; David J Goldhamer
Journal:  Bone       Date:  2018-01-31       Impact factor: 4.398

7.  Characterizing the Circulating Cell Populations in Traumatic Heterotopic Ossification.

Authors:  Shawn J Loder; Shailesh Agarwal; Michael T Chung; David Cholok; Charles Hwang; Noelle Visser; Kaetlin Vasquez; Michael Sorkin; Joe Habbouche; Hsiao H Sung; Joshua Peterson; David Fireman; Kavitha Ranganathan; Christopher Breuler; Caitlin Priest; John Li; Xue Bai; Shuli Li; Paul S Cederna; Benjamin Levi
Journal:  Am J Pathol       Date:  2018-08-22       Impact factor: 4.307

Review 8.  Macrophages and skeletal health.

Authors:  Megan N Michalski; Laurie K McCauley
Journal:  Pharmacol Ther       Date:  2017-02-07       Impact factor: 12.310

Review 9.  Adaptive immune cells in calcific aortic valve disease.

Authors:  Michael A Raddatz; Meena S Madhur; W David Merryman
Journal:  Am J Physiol Heart Circ Physiol       Date:  2019-05-03       Impact factor: 4.733

10.  Pregnancy in fibrodysplasia ossificans progressiva.

Authors:  Javaid A Muglu; Aditya Garg; T Pandiarajan; Eileen M Shore; Frederick S Kaplan; Dhiraj Uchil; Malcolm J Dickson
Journal:  Obstet Med       Date:  2011-12-08
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