Literature DB >> 18832153

Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole.

Richard W Wong1, Günter Blobel.   

Abstract

Accurate mitotic chromosome segregation depends on the formation of a microtubule-based bipolar spindle apparatus. We report that the cohesin subunit structural maintenance of chromosomes subunit 1 (SMC1) is recruited to microtubule-bound RNA export factor 1 (Rae1) at the mitotic spindle pole. We locate the Rae1-binding site to a 21-residue-long region, SMC1(947-967) and provide several lines of evidence that phosphorylation of Ser(957) and Ser(966) of SMC1 stimulates binding to Rae1. Imbalances in these assembly pathways caused formation of multipolar spindles. Our data suggest that cohesin's known bundling function for chromatids in mitotic and interphase cells extends to microtubules at the spindle pole.

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Year:  2008        PMID： 18832153      PMCID： PMC2557025          DOI： 10.1073/pnas.0807660105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.

Authors:  Seong-Tae Kim; Bo Xu; Michael B Kastan
Journal:  Genes Dev       Date:  2002-03-01       Impact factor: 11.361

Review 2.  The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair.

Authors:  Tatsuya Hirano
Journal:  Genes Dev       Date:  2002-02-15       Impact factor: 11.361

3.  The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins.

Authors:  X Wang; J R Babu; J M Harden; S A Jablonski; M H Gazi; W L Lingle; P C de Groen; T J Yen; J M van Deursen
Journal:  J Biol Chem       Date:  2001-05-14       Impact factor: 5.157

4.  Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

Authors:  Risa Kitagawa; Christopher J Bakkenist; Peter J McKinnon; Michael B Kastan
Journal:  Genes Dev       Date:  2004-06-02       Impact factor: 11.361

5.  Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators.

Authors:  William Stedman; Hyojeung Kang; Shu Lin; Joseph L Kissil; Marisa S Bartolomei; Paul M Lieberman
Journal:  EMBO J       Date:  2008-01-24       Impact factor: 11.598

6.  mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm.

Authors:  D Kraemer; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

7.  Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.

Authors:  T Gaglio; A Saredi; J B Bingham; M J Hasbani; S R Gill; T A Schroer; D A Compton
Journal:  J Cell Biol       Date:  1996-10       Impact factor: 10.539

8.  NuMA is required for the organization of microtubules into aster-like mitotic arrays.

Authors:  T Gaglio; A Saredi; D A Compton
Journal:  J Cell Biol       Date:  1995-11       Impact factor: 10.539

9.  RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains.

Authors:  C E Pritchard; M Fornerod; L H Kasper; J M van Deursen
Journal:  J Cell Biol       Date:  1999-04-19       Impact factor: 10.539

10.  NuMA is required for the proper completion of mitosis.

Authors:  D A Compton; D W Cleveland
Journal:  J Cell Biol       Date:  1993-02       Impact factor: 10.539
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  37 in total

1.  Is cohesin required for spindle-pole-body/centrosome cohesion?

Authors:  Hui Jin; Martin Avey; Hong-Guo Yu
Journal:  Commun Integr Biol       Date:  2012-01-01

2.  Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.

Authors:  Yi Ren; Hyuk-Soo Seo; Günter Blobel; André Hoelz
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-24       Impact factor: 11.205

Review 3.  Centrosomes in the DNA damage response--the hub outside the centre.

Authors:  Lisa I Mullee; Ciaran G Morrison
Journal:  Chromosome Res       Date:  2016-01       Impact factor: 5.239

Review 4.  Cohesins: chromatin architects in chromosome segregation, control of gene expression and much more.

Authors:  José L Barbero
Journal:  Cell Mol Life Sci       Date:  2009-03-17       Impact factor: 9.261

5.  Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells.

Authors:  Xiangduo Kong; Alexander R Ball; Eiichiro Sonoda; Jie Feng; Shunichi Takeda; Tatsuo Fukagawa; Tim J Yen; Kyoko Yokomori
Journal:  Mol Biol Cell       Date:  2008-12-30       Impact factor: 4.138

Review 6.  Sororin is a master regulator of sister chromatid cohesion and separation.

Authors:  Nenggang Zhang; Debananda Pati
Journal:  Cell Cycle       Date:  2012-06-01       Impact factor: 4.534

7.  Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.

Authors:  Jun Dai; Anna V Kateneva; Jonathan M G Higgins
Journal:  J Cell Sci       Date:  2009-11-15       Impact factor: 5.285

Review 8.  Separate to operate: control of centrosome positioning and separation.

Authors:  Fikret G Agircan; Elmar Schiebel; Balca R Mardin
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-09-05       Impact factor: 6.237

9.  Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A.

Authors:  Akiko Kobayashi; Chieko Hashizume; Takayuki Dowaki; Richard W Wong
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

10.  Characterization of the role of the tumor marker Nup88 in mitosis.

Authors:  Chieko Hashizume; Hiroshi Nakano; Kimihisa Yoshida; Richard W Wong
Journal:  Mol Cancer       Date:  2010-05-24       Impact factor: 27.401
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