| Literature DB >> 18832003 |
J C Lima-Junior1, T M Tran, E V S Meyer, B Singh, S G De-Simone, F Santos, C T Daniel-Ribeiro, A Moreno, J W Barnwell, M R Galinski, J Oliveira-Ferreira.
Abstract
Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRIIand PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied.Entities:
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Year: 2008 PMID： 18832003 PMCID： PMC4431613 DOI： 10.1016/j.vaccine.2008.09.029
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641